CCNE1 [The Human Chemical-Genetic Interaction Map Project]

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======= CCNE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNE1
  * **<color #00a2e8>Official Name</color>**: cyclin E1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=898|898]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24864|P24864]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123837|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin N|
|Cyclin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclin E1-CDK2 complex|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|cyclin-dependent protein kinase holoenzyme complex|
|DNA replication initiation|
|cyclin-dependent protein serine/threonine kinase regulator activity|
|positive regulation of G1/S transition of mitotic cell cycle|
|androgen receptor signaling pathway|
|androgen receptor binding|
|synapsis|
|positive regulation of cell cycle G1/S phase transition|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|intracellular steroid hormone receptor signaling pathway|
|positive regulation of mitotic cell cycle phase transition|
|meiotic chromosome segregation|
|positive regulation of cell cycle phase transition|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|telomere maintenance|
|telomere organization|
|regulation of cyclin-dependent protein kinase activity|
|meiosis I|
|meiosis I cell cycle process|
|steroid hormone mediated signaling pathway|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|DNA-dependent DNA replication|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|meiotic nuclear division|
|intracellular receptor signaling pathway|
|meiotic cell cycle process|
|regulation of cell cycle G1/S phase transition|
|hormone-mediated signaling pathway|
|cellular response to steroid hormone stimulus|
|DNA replication|
|nuclear chromosome segregation|
|meiotic cell cycle|
|protein kinase activity|
|mitotic cell cycle phase transition|
|chromosome segregation|
|cell cycle phase transition|
|transcription coactivator activity|
|nuclear division|
|positive regulation of cell cycle process|
|organelle fission|
|response to steroid hormone|
|anatomical structure homeostasis|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of cell cycle phase transition|
|protein kinase binding|
|centrosome|
|cell division|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|mitotic cell cycle process|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of protein kinase activity|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|protein phosphorylation|
|regulation of transferase activity|
|cell cycle process|
|regulation of protein localization|
|chromosome organization|
|cell-cell signaling|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|2/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|4/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13936
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNE1 Expression in NALM6 Cells: 4.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>