CCNE1
Gene Information
- Official Symbol: CCNE1
- Official Name: cyclin E1
- Aliases and Previous Symbols: N/A
- Entrez ID: 898
- UniProt: P24864
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}.
Pfam Domains GO Terms
Pfam Domains
| Cyclin N |
| Cyclin C |
GO Terms
| cyclin E1-CDK2 complex |
| regulation of transcription involved in G1/S transition of mitotic cell cycle |
| cyclin-dependent protein kinase holoenzyme complex |
| DNA replication initiation |
| cyclin-dependent protein serine/threonine kinase regulator activity |
| positive regulation of G1/S transition of mitotic cell cycle |
| androgen receptor signaling pathway |
| androgen receptor binding |
| synapsis |
| positive regulation of cell cycle G1/S phase transition |
| homologous chromosome segregation |
| chromosome organization involved in meiotic cell cycle |
| intracellular steroid hormone receptor signaling pathway |
| positive regulation of mitotic cell cycle phase transition |
| meiotic chromosome segregation |
| positive regulation of cell cycle phase transition |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| telomere maintenance |
| telomere organization |
| regulation of cyclin-dependent protein kinase activity |
| meiosis I |
| meiosis I cell cycle process |
| steroid hormone mediated signaling pathway |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| DNA-dependent DNA replication |
| regulation of G1/S transition of mitotic cell cycle |
| positive regulation of mitotic cell cycle |
| meiotic nuclear division |
| intracellular receptor signaling pathway |
| meiotic cell cycle process |
| regulation of cell cycle G1/S phase transition |
| hormone-mediated signaling pathway |
| cellular response to steroid hormone stimulus |
| DNA replication |
| nuclear chromosome segregation |
| meiotic cell cycle |
| protein kinase activity |
| mitotic cell cycle phase transition |
| chromosome segregation |
| cell cycle phase transition |
| transcription coactivator activity |
| nuclear division |
| positive regulation of cell cycle process |
| organelle fission |
| response to steroid hormone |
| anatomical structure homeostasis |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| positive regulation of cell cycle |
| regulation of mitotic cell cycle phase transition |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of cell cycle phase transition |
| protein kinase binding |
| centrosome |
| cell division |
| regulation of protein serine/threonine kinase activity |
| cellular response to lipid |
| regulation of cellular protein localization |
| cellular response to organic cyclic compound |
| mitotic cell cycle process |
| cellular response to hormone stimulus |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| DNA metabolic process |
| regulation of cell cycle process |
| regulation of protein kinase activity |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| protein phosphorylation |
| regulation of transferase activity |
| cell cycle process |
| regulation of protein localization |
| chromosome organization |
| cell-cell signaling |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| phosphorylation |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| NFN1 0.4μM R03 exp99 | 1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 10/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 2/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 4/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 13936
- Expression level (log2 read counts): 4.15
Expression Distribution
CCNE1 Expression in NALM6 Cells: 4.15
