CCNF [The Human Chemical-Genetic Interaction Map Project]

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======= CCNF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNF
  * **<color #00a2e8>Official Name</color>**: cyclin F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=899|899]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41002|P41002]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600227|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. {ECO:0000269|PubMed:20596027}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin N|
|F-box|
|Cyclin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|re-entry into mitotic cell cycle|
|negative regulation of centrosome duplication|
|negative regulation of centrosome cycle|
|cyclin-dependent protein kinase holoenzyme complex|
|cyclin-dependent protein serine/threonine kinase regulator activity|
|regulation of centrosome duplication|
|regulation of centrosome cycle|
|SCF ubiquitin ligase complex|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of cytoskeleton organization|
|centriole|
|placenta development|
|regulation of microtubule cytoskeleton organization|
|regulation of microtubule-based process|
|protein kinase activity|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|proteasomal protein catabolic process|
|post-translational protein modification|
|negative regulation of organelle organization|
|reproductive structure development|
|reproductive system development|
|protein kinase binding|
|centrosome|
|cell division|
|regulation of protein serine/threonine kinase activity|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cytoskeleton organization|
|modification-dependent macromolecule catabolic process|
|cell junction|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|developmental process involved in reproduction|
|protein catabolic process|
|mitotic cell cycle|
|protein ubiquitination|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|regulation of protein kinase activity|
|regulation of kinase activity|
|cellular macromolecule catabolic process|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of cell cycle|
|proteolysis|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.16|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.92|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.84|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.8|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.78|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.74|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.74|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.7|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.93|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.02|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.06|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.08|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.14|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.37|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|3.61|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|3.79|
|[[:results:exp59|UMK57 1μM R01 exp59]]|3.82|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|4.04|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|4.29|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|4.31|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|6.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atat1|ATAT1]]|0.449|
|[[:human genes:i:ino80e|INO80E]]|0.43|
|[[:human genes:a:atxn7l3|ATXN7L3]]|0.43|
|[[:human genes:t:tfap4|TFAP4]]|0.423|
|[[:human genes:n:numa1|NUMA1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2063
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNF Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>