CCNF

Gene Information

Official Symbol: CCNF
Official Name: cyclin F
Aliases and Previous Symbols: N/A
Entrez ID: 899
UniProt: P41002
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. {ECO:0000269|PubMed:20596027}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Methotrexate 0.01μM R08 exp501	-2.16
Arsenate 40μM R06 exp264	-1.92
Arsenic trioxide 60μM R08 exp449	-1.84
Etoposide 0.3μM R05 exp199	-1.8
Aminopterin 0.005μM R07 exp335	-1.78
CB-5083 0.4μM R08 exp468	-1.74
Talazoparib 0.006μM R06 exp299	-1.74
GSK461364A 0.005μM R03 exp125	1.7
MSC2530818 10μM R07 exp379	1.93
Vinblastine 0.002μM R01 exp60	2
BVD-523 15μM R02 exp67	2.02
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.06
2-Methoxyestradiol 0.55μM R07 exp310	2.08
Docetaxel 0.002μM R01 exp45	2.14
UM131593 0.2μM R03 exp106	3.37
BI-6727 0.0125μM R03 exp97	3.61
Vincristine 0.0005μM R04 exp190	3.79
UMK57 1μM R01 exp59	3.82
BML-284 0.09μM R08 exp460	4.04
Mdivi-1 15μM R05 exp217	4.29
BI-2536 0.0042μM R03 exp95	4.31
RO-3307 4.7μM R02 exp80	6.32

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2063
Expression level (log2 read counts): 7.14

Expression Distribution

Gene	Correlation
ATAT1	0.449
INO80E	0.43
ATXN7L3	0.43
TFAP4	0.423
NUMA1	0.411

Cyclin N
F-box
Cyclin C

re-entry into mitotic cell cycle
negative regulation of centrosome duplication
negative regulation of centrosome cycle
cyclin-dependent protein kinase holoenzyme complex
cyclin-dependent protein serine/threonine kinase regulator activity
regulation of centrosome duplication
regulation of centrosome cycle
SCF ubiquitin ligase complex
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
negative regulation of cytoskeleton organization
centriole
placenta development
regulation of microtubule cytoskeleton organization
regulation of microtubule-based process
protein kinase activity
mitotic cell cycle phase transition
cell cycle phase transition
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of cell cycle process
proteasomal protein catabolic process
post-translational protein modification
negative regulation of organelle organization
reproductive structure development
reproductive system development
protein kinase binding
centrosome
cell division
regulation of protein serine/threonine kinase activity
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
regulation of cytoskeleton organization
modification-dependent macromolecule catabolic process
cell junction
negative regulation of cell cycle
proteolysis involved in cellular protein catabolic process
mitotic cell cycle process
cellular protein catabolic process