CCNK [The Human Chemical-Genetic Interaction Map Project]

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======= CCNK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNK
  * **<color #00a2e8>Official Name</color>**: cyclin K
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8812|8812]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75909|O75909]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603544|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). {ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:9632813}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues|
|positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues|
|positive regulation of phosphorylation of RNA polymerase II C-terminal domain|
|cyclin K-CDK13 complex|
|cyclin K-CDK12 complex|
|regulation of phosphorylation of RNA polymerase II C-terminal domain|
|negative regulation by host of viral genome replication|
|cyclin/CDK positive transcription elongation factor complex|
|cyclin-dependent protein serine/threonine kinase activator activity|
|negative regulation by host of viral process|
|modulation by host of viral genome replication|
|RNA polymerase II CTD heptapeptide repeat kinase activity|
|negative regulation of cell cycle arrest|
|modulation by host of viral process|
|cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of DNA-templated transcription, elongation|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|cyclin-dependent protein serine/threonine kinase regulator activity|
|positive regulation of cyclin-dependent protein kinase activity|
|regulation of DNA-templated transcription, elongation|
|negative regulation of viral genome replication|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|modification by host of symbiont morphology or physiology|
|transcription elongation from RNA polymerase II promoter|
|interaction with symbiont|
|negative regulation of viral life cycle|
|DNA-templated transcription, elongation|
|regulation of viral genome replication|
|ncRNA transcription|
|negative regulation of viral process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|regulation of cell cycle arrest|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of viral life cycle|
|modification of morphology or physiology of other organism|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of cell cycle process|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of cell cycle|
|protein kinase binding|
|transcription by RNA polymerase II|
|cell division|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|positive regulation of transferase activity|
|regulation of cell cycle process|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of kinase activity|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.29|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.81|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.74|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.75|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.96|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.49|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.53|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|4.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:ttc14|TTC14]]|0.532|
|[[:human genes:f:fam58a|FAM58A]]|0.502|
|[[:human genes:r:rprd1b|RPRD1B]]|0.477|
|[[:human genes:c:cdk10|CDK10]]|0.434|
|[[:human genes:d:dazap1|DAZAP1]]|0.411|
|[[:human genes:c:cdk12|CDK12]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 187/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|8/28|
|bone|6/26|
|breast|9/33|
|central nervous system|20/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|8/21|
|liver|5/20|
|lung|12/75|
|lymphocyte|5/16|
|ovary|7/26|
|pancreas|4/24|
|peripheral nervous system|6/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|1/22|
|urinary tract|8/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 901
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNK Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>