CCNK
Gene Information
- Official Symbol: CCNK
- Official Name: cyclin K
- Aliases and Previous Symbols: N/A
- Entrez ID: 8812
- UniProt: O75909
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). {ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:9632813}.
Pfam Domains GO Terms
Pfam Domains
| Cyclin N |
GO Terms
| regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues |
| positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues |
| positive regulation of phosphorylation of RNA polymerase II C-terminal domain |
| cyclin K-CDK13 complex |
| cyclin K-CDK12 complex |
| regulation of phosphorylation of RNA polymerase II C-terminal domain |
| negative regulation by host of viral genome replication |
| cyclin/CDK positive transcription elongation factor complex |
| cyclin-dependent protein serine/threonine kinase activator activity |
| negative regulation by host of viral process |
| modulation by host of viral genome replication |
| RNA polymerase II CTD heptapeptide repeat kinase activity |
| negative regulation of cell cycle arrest |
| modulation by host of viral process |
| cyclin-dependent protein serine/threonine kinase activity |
| positive regulation of DNA-templated transcription, elongation |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| cyclin-dependent protein serine/threonine kinase regulator activity |
| positive regulation of cyclin-dependent protein kinase activity |
| regulation of DNA-templated transcription, elongation |
| negative regulation of viral genome replication |
| snRNA transcription by RNA polymerase II |
| snRNA transcription |
| modification by host of symbiont morphology or physiology |
| transcription elongation from RNA polymerase II promoter |
| interaction with symbiont |
| negative regulation of viral life cycle |
| DNA-templated transcription, elongation |
| regulation of viral genome replication |
| ncRNA transcription |
| negative regulation of viral process |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| regulation of cell cycle arrest |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| regulation of viral life cycle |
| modification of morphology or physiology of other organism |
| regulation of viral process |
| negative regulation of multi-organism process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| negative regulation of cell cycle process |
| positive regulation of protein serine/threonine kinase activity |
| positive regulation of cell cycle |
| protein kinase binding |
| transcription by RNA polymerase II |
| cell division |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| positive regulation of transferase activity |
| regulation of cell cycle process |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| symbiotic process |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| regulation of kinase activity |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| nucleobase-containing compound biosynthetic process |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| cell cycle |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular response to stress |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 187/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 6/28 |
| blood | 8/28 |
| bone | 6/26 |
| breast | 9/33 |
| central nervous system | 20/56 |
| cervix | 1/4 |
| colorectal | 2/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 5/16 |
| kidney | 8/21 |
| liver | 5/20 |
| lung | 12/75 |
| lymphocyte | 5/16 |
| ovary | 7/26 |
| pancreas | 4/24 |
| peripheral nervous system | 6/16 |
| plasma cell | 5/15 |
| prostate | 0/1 |
| skin | 5/24 |
| soft tissue | 6/9 |
| thyroid | 1/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 8/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 901
- Expression level (log2 read counts): 5.8
Expression Distribution
CCNK Expression in NALM6 Cells: 5.8
