CCNL1 [The Human Chemical-Genetic Interaction Map Project]

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======= CCNL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNL1
  * **<color #00a2e8>Official Name</color>**: cyclin L1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57018|57018]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UK58|Q9UK58]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613384|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclin-dependent protein serine/threonine kinase regulator activity|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|nuclear speck|
|regulation of protein serine/threonine kinase activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|RNA processing|
|regulation of transferase activity|
|regulation of cell cycle|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.11|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.05|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.72|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.73|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.74|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.74|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.76|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.78|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.78|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.79|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.8|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.98|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.01|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.02|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.05|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.15|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.15|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.15|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.2|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.21|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.28|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.3|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.36|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.56|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.67|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.72|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.82|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|3.04|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccnl2|CCNL2]]|0.481|
|[[:human genes:e:eif4a1|EIF4A1]]|0.44|
|[[:human genes:c:c9orf78|C9orf78]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 52/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|4/26|
|breast|1/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|7/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8634
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNL1 Expression in NALM6 Cells: 8.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>