CCNL1

Entrez Summary: N/A
UniProt Summary: Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 52/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	4/26
breast	1/33
central nervous system	5/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	3/21
liver	1/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	2/24
peripheral nervous system	7/16
plasma cell	2/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	3/29
uterus	1/5

Expression Distribution

cyclin-dependent protein serine/threonine kinase regulator activity
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
nuclear speck
regulation of protein serine/threonine kinase activity
regulation of protein kinase activity
regulation of kinase activity
RNA processing
regulation of transferase activity
regulation of cell cycle
regulation of protein phosphorylation
regulation of phosphorylation
RNA metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
gene expression