CCR4

Entrez Summary: N/A
UniProt Summary: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269|PubMed:10466728, ECO:0000269|PubMed:10754297, ECO:0000269|PubMed:16137713, ECO:0000269|PubMed:9169480, ECO:0000269|PubMed:9430724}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7tm 1
7TM GPCR Srsx

tolerance induction
chemokine receptor activity
C-C chemokine receptor activity
C-C chemokine binding
chemokine binding
positive regulation of positive chemotaxis
regulation of positive chemotaxis
chemokine-mediated signaling pathway
cellular response to chemokine
response to chemokine
neuron migration
positive regulation of chemotaxis
calcium-mediated signaling
homeostasis of number of cells
cell chemotaxis
regulation of chemotaxis
positive regulation of cytosolic calcium ion concentration
response to antibiotic
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
neuronal cell body
external side of plasma membrane
cellular calcium ion homeostasis
response to radiation
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
inflammatory response
chemotaxis
taxis
positive regulation of locomotion
cellular metal ion homeostasis
positive regulation of response to external stimulus
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
immune system development
cytokine-mediated signaling pathway
response to bacterium
cation homeostasis