CCSAP

Entrez Summary: N/A
UniProt Summary: Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity). {ECO:0000250|UniProtKB:Q6P3G4, ECO:0000269|PubMed:26562023}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitotic spindle microtubule depolymerization
mitotic spindle astral microtubule
regulation of cilium beat frequency involved in ciliary motility
regulation of cilium movement involved in cell motility
regulation of cilium beat frequency
regulation of cilium movement
microtubule depolymerization
regulation of mitotic spindle assembly
regulation of cilium-dependent cell motility
ciliary transition zone
regulation of spindle assembly
regulation of microtubule-based movement
protein depolymerization
regulation of mitotic spindle organization
regulation of spindle organization
microtubule polymerization or depolymerization
mitotic spindle
axoneme
spindle
regulation of embryonic development
ciliary basal body
cellular protein complex disassembly
centriole
regulation of mitotic nuclear division
regulation of microtubule cytoskeleton organization
regulation of nuclear division
cilium
regulation of organelle assembly
regulation of microtubule-based process
microtubule binding
protein-containing complex disassembly
axon
cellular component disassembly
supramolecular fiber organization
microtubule cytoskeleton organization
centrosome
cell division
regulation of cytoskeleton organization
regulation of mitotic cell cycle
microtubule-based process