CCT6A [The Human Chemical-Genetic Interaction Map Project]

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======= CCT6A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCT6A
  * **<color #00a2e8>Official Name</color>**: chaperonin containing TCP1 subunit 6A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=908|908]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40227|P40227]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCT6A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCT6A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104613|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cpn60 TCP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|WD40-repeat domain binding|
|positive regulation of protein localization to Cajal body|
|regulation of protein localization to Cajal body|
|positive regulation of establishment of protein localization to telomere|
|chaperonin-containing T-complex|
|regulation of establishment of protein localization to telomere|
|positive regulation of protein localization to chromosome, telomeric region|
|regulation of establishment of protein localization to chromosome|
|regulation of protein localization to chromosome, telomeric region|
|positive regulation of telomerase RNA localization to Cajal body|
|regulation of telomerase RNA localization to Cajal body|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomere maintenance via telomere lengthening|
|positive regulation of telomere maintenance|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|positive regulation of DNA biosynthetic process|
|positive regulation of protein localization to nucleus|
|regulation of telomere maintenance|
|regulation of DNA biosynthetic process|
|regulation of protein localization to nucleus|
|unfolded protein binding|
|positive regulation of chromosome organization|
|protein stabilization|
|positive regulation of DNA metabolic process|
|protein folding|
|regulation of protein stability|
|microtubule|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|regulation of establishment of protein localization|
|regulation of cellular localization|
|regulation of protein localization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|RNA binding|
|ATP binding|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.25|
|[[:results:exp303|39°C R06 exp303]]|-2.23|
|[[:results:exp218|A-395 10μM R05 exp218]]|-2|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.78|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.77|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.74|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.73|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.74|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.95|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|2.09|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.571|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 258/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|15/28|
|bone|7/26|
|breast|15/33|
|central nervous system|26/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|5/16|
|kidney|6/21|
|liver|6/20|
|lung|18/75|
|lymphocyte|8/16|
|ovary|8/26|
|pancreas|4/24|
|peripheral nervous system|6/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|6/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1042
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCT6A Expression in NALM6 Cells: 8.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>