CCT6A

Gene Information

Official Symbol: CCT6A
Official Name: chaperonin containing TCP1 subunit 6A
Aliases and Previous Symbols: N/A
Entrez ID: 908
UniProt: P40227
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lapatinib 5μM R01 exp47	-2.25
39°C R06 exp303	-2.23
A-395 10μM R05 exp218	-2
QNZ 0.01μM R05 exp241	-2
Pomalidomide 20μM R07 exp391	-1.78
Deguelin 0.15μM R05 exp209	-1.77
UNC1999 2μM R03 exp155	-1.74
Etoposide 1μM R00 exp19	1.73
Nocodazole 0.2μM R00 exp24	1.74
Rotenone 20μM R00 exp34	1.95
Etoposide 10μM R00 exp20	2.09
Actinomycin-D 0.01μM R00 exp4	2.78

Global Fraction of Cell Lines Where Essential: 258/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	11/28
blood	15/28
bone	7/26
breast	15/33
central nervous system	26/56
cervix	2/4
colorectal	7/17
esophagus	3/13
fibroblast	1/1
gastric	5/16
kidney	6/21
liver	6/20
lung	18/75
lymphocyte	8/16
ovary	8/26
pancreas	4/24
peripheral nervous system	6/16
plasma cell	6/15
prostate	1/1
skin	5/24
soft tissue	4/9
thyroid	1/2
upper aerodigestive	4/22
urinary tract	6/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1042
Expression level (log2 read counts): 8.86

Expression Distribution

WD40-repeat domain binding
positive regulation of protein localization to Cajal body
regulation of protein localization to Cajal body
positive regulation of establishment of protein localization to telomere
chaperonin-containing T-complex
regulation of establishment of protein localization to telomere
positive regulation of protein localization to chromosome, telomeric region
regulation of establishment of protein localization to chromosome
regulation of protein localization to chromosome, telomeric region
positive regulation of telomerase RNA localization to Cajal body
regulation of telomerase RNA localization to Cajal body
positive regulation of telomere maintenance via telomerase
positive regulation of telomere maintenance via telomere lengthening
positive regulation of telomere maintenance
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
positive regulation of DNA biosynthetic process
positive regulation of protein localization to nucleus
regulation of telomere maintenance
regulation of DNA biosynthetic process
regulation of protein localization to nucleus
unfolded protein binding
positive regulation of chromosome organization
protein stabilization
positive regulation of DNA metabolic process
protein folding
regulation of protein stability
microtubule
positive regulation of cellular protein localization
regulation of chromosome organization
regulation of DNA metabolic process
positive regulation of establishment of protein localization
regulation of cellular protein localization
positive regulation of organelle organization
regulation of establishment of protein localization
regulation of cellular localization
regulation of protein localization
positive regulation of cellular component organization
regulation of organelle organization
RNA binding