CCT8 [The Human Chemical-Genetic Interaction Map Project]

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======= CCT8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCT8
  * **<color #00a2e8>Official Name</color>**: chaperonin containing TCP1 subunit 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10694|10694]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50990|P50990]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCT8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCT8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617786|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cpn60 TCP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|zona pellucida receptor complex|
|positive regulation of protein localization to Cajal body|
|regulation of protein localization to Cajal body|
|positive regulation of establishment of protein localization to telomere|
|regulation of establishment of protein localization to telomere|
|chaperonin-containing T-complex|
|regulation of establishment of protein localization to chromosome|
|positive regulation of protein localization to chromosome, telomeric region|
|regulation of protein localization to chromosome, telomeric region|
|positive regulation of telomerase RNA localization to Cajal body|
|regulation of telomerase RNA localization to Cajal body|
|pore complex assembly|
|ATPase activity, coupled|
|positive regulation of telomere maintenance via telomerase|
|binding of sperm to zona pellucida|
|positive regulation of telomere maintenance via telomere lengthening|
|toxin transport|
|intermediate filament cytoskeleton|
|positive regulation of telomere maintenance|
|sperm-egg recognition|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|positive regulation of DNA biosynthetic process|
|cell-cell recognition|
|cell body|
|positive regulation of protein localization to nucleus|
|regulation of telomere maintenance|
|azurophil granule lumen|
|regulation of DNA biosynthetic process|
|secretory granule lumen|
|regulation of protein localization to nucleus|
|ficolin-1-rich granule lumen|
|unfolded protein binding|
|single fertilization|
|fertilization|
|positive regulation of chromosome organization|
|protein stabilization|
|positive regulation of DNA metabolic process|
|cilium|
|protein folding|
|cell recognition|
|regulation of protein stability|
|cadherin binding|
|microtubule|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of establishment of protein localization|
|neutrophil degranulation|
|centrosome|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of cellular protein localization|
|myeloid leukocyte activation|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|regulation of establishment of protein localization|
|leukocyte mediated immunity|
|exocytosis|
|sexual reproduction|
|regulation of cellular localization|
|leukocyte activation|
|multi-organism reproductive process|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|reproductive process|
|reproduction|
|ATP binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.76|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.71|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.71|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.73|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.74|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.84|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.07|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.15|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.24|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.37|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.56|
|[[:results:exp115|A-366 10μM R03 exp115]]|2.67|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.424|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 318/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|11/28|
|bone|12/26|
|breast|16/33|
|central nervous system|35/56|
|cervix|2/4|
|colorectal|6/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|7/21|
|liver|8/20|
|lung|25/75|
|lymphocyte|8/16|
|ovary|9/26|
|pancreas|5/24|
|peripheral nervous system|5/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|11/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|13/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 661
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCT8 Expression in NALM6 Cells: 8.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>