CCT8

Gene Information

Official Symbol: CCT8
Official Name: chaperonin containing TCP1 subunit 8
Aliases and Previous Symbols: N/A
Entrez ID: 10694
UniProt: P50990
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Sulforaphane 9μM R08 exp525	-1.76
Cabazitaxel 0.001μM R05 exp223	1.71
LY2090314 0.003μM R08 exp499	1.71
Actinomycin-D 0.01μM R00 exp4	1.73
Nicotinamide 2000μM R01 exp50	1.74
Golgicide-A 4μM R03 exp122	1.84
Pimelic-diphenylamide-106 5μM R00 exp28	2.07
Quinacrine 2.5μM R03 exp146	2.15
Etoposide 1μM R00 exp19	2.24
S-DABN 8μM R03 exp112	2.37
THZ531 0.225μM R08 exp444	2.56
A-366 10μM R03 exp115	2.67
Nifurtimox 1μM R03 exp141	2.87

Global Fraction of Cell Lines Where Essential: 318/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	13/28
blood	11/28
bone	12/26
breast	16/33
central nervous system	35/56
cervix	2/4
colorectal	6/17
esophagus	3/13
fibroblast	0/1
gastric	6/16
kidney	7/21
liver	8/20
lung	25/75
lymphocyte	8/16
ovary	9/26
pancreas	5/24
peripheral nervous system	5/16
plasma cell	3/15
prostate	0/1
skin	11/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	13/22
urinary tract	13/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 661
Expression level (log2 read counts): 8.4

Expression Distribution

zona pellucida receptor complex
positive regulation of protein localization to Cajal body
regulation of protein localization to Cajal body
positive regulation of establishment of protein localization to telomere
regulation of establishment of protein localization to telomere
chaperonin-containing T-complex
regulation of establishment of protein localization to chromosome
positive regulation of protein localization to chromosome, telomeric region
regulation of protein localization to chromosome, telomeric region
positive regulation of telomerase RNA localization to Cajal body
regulation of telomerase RNA localization to Cajal body
pore complex assembly
ATPase activity, coupled
positive regulation of telomere maintenance via telomerase
binding of sperm to zona pellucida
positive regulation of telomere maintenance via telomere lengthening
toxin transport
intermediate filament cytoskeleton
positive regulation of telomere maintenance
sperm-egg recognition
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
positive regulation of DNA biosynthetic process
cell-cell recognition
cell body
positive regulation of protein localization to nucleus
regulation of telomere maintenance
azurophil granule lumen
regulation of DNA biosynthetic process
secretory granule lumen
regulation of protein localization to nucleus
ficolin-1-rich granule lumen
unfolded protein binding
single fertilization
fertilization
positive regulation of chromosome organization
protein stabilization
positive regulation of DNA metabolic process
cilium
protein folding