CD151
Gene Information
- Official Symbol: CD151
- Official Name: CD151 molecule (Raph blood group)
- Aliases and Previous Symbols: N/A
- Entrez ID: 977
- UniProt: P48509
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record represents the CD151*001.1.1 allele.
- UniProt Summary: Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. {ECO:0000269|PubMed:15265795}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14536
- Expression level (log2 read counts): 4.7
CD151 Expression in NALM6 Cells: 4.7
