CD1A

Gene Information

Official Symbol: CD1A
Official Name: CD1a molecule
Aliases and Previous Symbols: N/A
Entrez ID: 909
UniProt: P06126
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:11231314, ECO:0000269|PubMed:16272286, ECO:0000269|PubMed:18178838}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7868
Expression level (log2 read counts): -5.6

Expression Distribution

MHC I
C1-set

exogenous lipid antigen binding
antigen processing and presentation, endogenous lipid antigen via MHC class Ib
endogenous lipid antigen binding
antigen processing and presentation, exogenous lipid antigen via MHC class Ib
antigen processing and presentation of lipid antigen via MHC class Ib
lipopeptide binding
antigen processing and presentation via MHC class Ib
antigen processing and presentation of endogenous antigen
positive regulation of T cell mediated cytotoxicity
regulation of T cell mediated cytotoxicity
positive regulation of T cell mediated immunity
positive regulation of leukocyte mediated cytotoxicity
positive regulation of cell killing
regulation of T cell mediated immunity
regulation of leukocyte mediated cytotoxicity
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of cell killing
positive regulation of lymphocyte mediated immunity
positive regulation of adaptive immune response
positive regulation of leukocyte mediated immunity
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of lymphocyte mediated immunity
regulation of adaptive immune response
antigen processing and presentation of exogenous antigen
regulation of leukocyte mediated immunity
endosome membrane
antigen processing and presentation
positive regulation of immune effector process
membrane raft
external side of plasma membrane
regulation of immune effector process
adaptive immune response
positive regulation of immune response
positive regulation of immune system process
regulation of immune response
integral component of plasma membrane
extracellular space
regulation of immune system process
immune response