CD1D [The Human Chemical-Genetic Interaction Map Project]

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======= CD1D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD1D
  * **<color #00a2e8>Official Name</color>**: CD1d molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=912|912]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15813|P15813]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD1D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD1D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:17475845}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MHC I|
|C1-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipid antigen binding|
|antigen processing and presentation, endogenous lipid antigen via MHC class Ib|
|exogenous lipid antigen binding|
|endogenous lipid antigen binding|
|antigen processing and presentation of lipid antigen via MHC class Ib|
|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|
|beta-2-microglobulin binding|
|lipopeptide binding|
|detection of bacterium|
|detection of other organism|
|antigen processing and presentation via MHC class Ib|
|detection of external biotic stimulus|
|antigen processing and presentation of endogenous antigen|
|detection of biotic stimulus|
|positive regulation of T cell mediated cytotoxicity|
|regulation of T cell mediated cytotoxicity|
|heterotypic cell-cell adhesion|
|T cell selection|
|positive regulation of T cell mediated immunity|
|positive regulation of leukocyte mediated cytotoxicity|
|cell adhesion molecule binding|
|positive regulation of cell killing|
|regulation of T cell mediated immunity|
|regulation of leukocyte mediated cytotoxicity|
|positive regulation of T cell proliferation|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|histone binding|
|positive regulation of leukocyte mediated immunity|
|T cell differentiation|
|positive regulation of leukocyte proliferation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|antigen processing and presentation of exogenous antigen|
|basolateral plasma membrane|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|endosome membrane|
|positive regulation of leukocyte cell-cell adhesion|
|antigen processing and presentation|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|T cell activation|
|lymphocyte differentiation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|lysosomal membrane|
|regulation of T cell activation|
|leukocyte differentiation|
|positive regulation of innate immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|cell-cell adhesion|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|hemopoiesis|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|cell surface|
|regulation of cell activation|
|immune system development|
|regulation of cell adhesion|
|detection of stimulus|
|response to bacterium|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|defense response to other organism|
|endoplasmic reticulum|
|cell activation|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|extracellular space|
|regulation of cell population proliferation|
|regulation of immune system process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.05|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.72|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14589
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD1D Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>