CD1D
Gene Information
- Official Symbol: CD1D
- Official Name: CD1d molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 912
- UniProt: P15813
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:17475845}.
Pfam Domains GO Terms
Pfam Domains
| MHC I |
| C1-set |
GO Terms
| lipid antigen binding |
| antigen processing and presentation, endogenous lipid antigen via MHC class Ib |
| exogenous lipid antigen binding |
| endogenous lipid antigen binding |
| antigen processing and presentation of lipid antigen via MHC class Ib |
| antigen processing and presentation, exogenous lipid antigen via MHC class Ib |
| beta-2-microglobulin binding |
| lipopeptide binding |
| detection of bacterium |
| detection of other organism |
| antigen processing and presentation via MHC class Ib |
| detection of external biotic stimulus |
| antigen processing and presentation of endogenous antigen |
| detection of biotic stimulus |
| positive regulation of T cell mediated cytotoxicity |
| regulation of T cell mediated cytotoxicity |
| heterotypic cell-cell adhesion |
| T cell selection |
| positive regulation of T cell mediated immunity |
| positive regulation of leukocyte mediated cytotoxicity |
| cell adhesion molecule binding |
| positive regulation of cell killing |
| regulation of T cell mediated immunity |
| regulation of leukocyte mediated cytotoxicity |
| positive regulation of T cell proliferation |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of cell killing |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| histone binding |
| positive regulation of leukocyte mediated immunity |
| T cell differentiation |
| positive regulation of leukocyte proliferation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of lymphocyte mediated immunity |
| regulation of T cell proliferation |
| regulation of adaptive immune response |
| antigen processing and presentation of exogenous antigen |
| basolateral plasma membrane |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| endosome membrane |
| positive regulation of leukocyte cell-cell adhesion |
| antigen processing and presentation |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| T cell activation |
| lymphocyte differentiation |
| positive regulation of cell-cell adhesion |
| regulation of leukocyte cell-cell adhesion |
| lysosomal membrane |
| regulation of T cell activation |
| leukocyte differentiation |
| positive regulation of innate immune response |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| lymphocyte activation |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| cell-cell adhesion |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| hemopoiesis |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| cell surface |
| regulation of cell activation |
| immune system development |
| regulation of cell adhesion |
| detection of stimulus |
| response to bacterium |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| positive regulation of immune response |
| positive regulation of cell population proliferation |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| endoplasmic reticulum membrane |
| defense response to other organism |
| endoplasmic reticulum |
| cell activation |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| integral component of plasma membrane |
| regulation of response to stress |
| extracellular space |
| regulation of cell population proliferation |
| regulation of immune system process |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| TNF-alpha 44ng/ml R08 exp533 | -2.05 |
| Doxorubicin 0.02μM R08 exp478 | -1.72 |
| Etoposide 1μM R00 exp19 | -1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14589
- Expression level (log2 read counts): -5.6
Expression Distribution
CD1D Expression in NALM6 Cells: -5.6
