CD200
Gene Information
- Official Symbol: CD200
- Official Name: CD200 molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 4345
- UniProt: P41217
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Pfam Domains GO Terms
Pfam Domains
| ig |
| V-set |
GO Terms
| regulation of arginase activity |
| positive regulation of arginase activity |
| regulation of protein-glutamine gamma-glutamyltransferase activity |
| regulation of matrix metallopeptidase secretion |
| glycosylated region protein binding |
| negative regulation of matrix metallopeptidase secretion |
| positive regulation of protein-glutamine gamma-glutamyltransferase activity |
| negative regulation of T cell migration |
| protein binding involved in heterotypic cell-cell adhesion |
| negative regulation of macrophage migration |
| negative regulation of interleukin-6 secretion |
| negative regulation of neuroinflammatory response |
| negative regulation of lymphocyte migration |
| negative regulation of macrophage activation |
| positive regulation of transforming growth factor beta production |
| positive regulation of CREB transcription factor activity |
| regulation of neuroinflammatory response |
| regulation of transforming growth factor beta production |
| heterotypic cell-cell adhesion |
| regulation of macrophage migration |
| negative regulation of interleukin-6 production |
| regulation of T cell migration |
| negative regulation of leukocyte migration |
| regulation of macrophage activation |
| regulation of lymphocyte migration |
| negative regulation of cytokine secretion |
| cell body |
| negative regulation of NF-kappaB transcription factor activity |
| negative regulation of protein secretion |
| negative regulation of inflammatory response |
| negative regulation of peptide secretion |
| regulation of interleukin-6 production |
| negative regulation of DNA-binding transcription factor activity |
| negative regulation of leukocyte activation |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| regulation of leukocyte migration |
| negative regulation of cell activation |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| negative regulation of neuron death |
| negative regulation of defense response |
| negative regulation of secretion |
| negative regulation of cell migration |
| positive regulation of DNA-binding transcription factor activity |
| negative regulation of cytokine production |
| negative regulation of cell motility |
| axon |
| negative regulation of cellular component movement |
| regulation of neuron death |
| neuron projection |
| negative regulation of locomotion |
| regulation of inflammatory response |
| negative regulation of response to external stimulus |
| neuronal cell body |
| regulation of DNA-binding transcription factor activity |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of protein secretion |
| negative regulation of transport |
| regulation of peptide secretion |
| cell-cell adhesion |
| regulation of leukocyte activation |
| cell surface |
| regulation of cell activation |
| positive regulation of transferase activity |
| negative regulation of cell population proliferation |
| regulation of cytokine production |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| positive regulation of hydrolase activity |
| regulation of secretion |
| regulation of cell migration |
| regulation of cell motility |
| cell adhesion |
| biological adhesion |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| regulation of protein localization |
| regulation of response to external stimulus |
| negative regulation of molecular function |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| regulation of hydrolase activity |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of response to stress |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9315
- Expression level (log2 read counts): 0.56
Expression Distribution
CD200 Expression in NALM6 Cells: 0.56
