CD274 [The Human Chemical-Genetic Interaction Map Project]

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======= CD274 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD274
  * **<color #00a2e8>Official Name</color>**: CD274 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29126|29126]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZQ7|Q9NZQ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD274&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD274|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605402|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1-set|
|V-set|
|C2-set 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process|
|regulation of tolerance induction to tumor cell|
|positive regulation of tolerance induction to tumor cell|
|regulation of activated CD4-positive, alpha-beta T cell apoptotic process|
|positive regulation of tolerance induction dependent upon immune response|
|regulation of activated CD8-positive, alpha-beta T cell apoptotic process|
|regulation of peripheral tolerance induction|
|positive regulation of peripheral tolerance induction|
|regulation of tolerance induction dependent upon immune response|
|negative regulation of CD8-positive, alpha-beta T cell activation|
|positive regulation of interleukin-10 secretion|
|negative regulation of CD4-positive, alpha-beta T cell proliferation|
|regulation of interleukin-10 secretion|
|positive regulation of tolerance induction|
|negative regulation of alpha-beta T cell proliferation|
|negative regulation of activated T cell proliferation|
|positive regulation of immune response to tumor cell|
|regulation of CD4-positive, alpha-beta T cell proliferation|
|positive regulation of response to tumor cell|
|regulation of response to tumor cell|
|regulation of immune response to tumor cell|
|positive regulation of T cell apoptotic process|
|regulation of CD8-positive, alpha-beta T cell activation|
|regulation of tolerance induction|
|positive regulation of lymphocyte apoptotic process|
|negative regulation of interleukin-10 production|
|positive regulation of leukocyte apoptotic process|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell proliferation|
|regulation of T cell apoptotic process|
|negative regulation of interferon-gamma production|
|positive regulation of interleukin-10 production|
|regulation of activated T cell proliferation|
|negative regulation of alpha-beta T cell activation|
|toxin transport|
|regulation of interleukin-10 production|
|regulation of lymphocyte apoptotic process|
|T cell costimulation|
|lymphocyte costimulation|
|negative regulation of T cell proliferation|
|regulation of CD4-positive, alpha-beta T cell activation|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|regulation of leukocyte apoptotic process|
|recycling endosome membrane|
|regulation of alpha-beta T cell activation|
|positive regulation of T cell proliferation|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|positive regulation of cytokine secretion|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of tumor necrosis factor superfamily cytokine production|
|early endosome membrane|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|regulation of cytokine secretion|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|positive regulation of cell-cell adhesion|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|regulation of leukocyte activation|
|adaptive immune response|
|cell surface|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18126
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD274 Expression in NALM6 Cells: 0.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>