CD274
Gene Information
- Official Symbol: CD274
- Official Name: CD274 molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 29126
- UniProt: Q9NZQ7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.
Pfam Domains GO Terms
Pfam Domains
| C1-set |
| V-set |
| C2-set 2 |
GO Terms
| positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process |
| regulation of tolerance induction to tumor cell |
| positive regulation of tolerance induction to tumor cell |
| regulation of activated CD4-positive, alpha-beta T cell apoptotic process |
| positive regulation of tolerance induction dependent upon immune response |
| regulation of activated CD8-positive, alpha-beta T cell apoptotic process |
| regulation of peripheral tolerance induction |
| positive regulation of peripheral tolerance induction |
| regulation of tolerance induction dependent upon immune response |
| negative regulation of CD8-positive, alpha-beta T cell activation |
| positive regulation of interleukin-10 secretion |
| negative regulation of CD4-positive, alpha-beta T cell proliferation |
| regulation of interleukin-10 secretion |
| positive regulation of tolerance induction |
| negative regulation of alpha-beta T cell proliferation |
| negative regulation of activated T cell proliferation |
| positive regulation of immune response to tumor cell |
| regulation of CD4-positive, alpha-beta T cell proliferation |
| positive regulation of response to tumor cell |
| regulation of response to tumor cell |
| regulation of immune response to tumor cell |
| positive regulation of T cell apoptotic process |
| regulation of CD8-positive, alpha-beta T cell activation |
| regulation of tolerance induction |
| positive regulation of lymphocyte apoptotic process |
| negative regulation of interleukin-10 production |
| positive regulation of leukocyte apoptotic process |
| negative regulation of CD4-positive, alpha-beta T cell activation |
| regulation of alpha-beta T cell proliferation |
| regulation of T cell apoptotic process |
| negative regulation of interferon-gamma production |
| positive regulation of interleukin-10 production |
| regulation of activated T cell proliferation |
| negative regulation of alpha-beta T cell activation |
| toxin transport |
| regulation of interleukin-10 production |
| regulation of lymphocyte apoptotic process |
| T cell costimulation |
| lymphocyte costimulation |
| negative regulation of T cell proliferation |
| regulation of CD4-positive, alpha-beta T cell activation |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| negative regulation of mononuclear cell proliferation |
| negative regulation of lymphocyte proliferation |
| negative regulation of leukocyte proliferation |
| regulation of leukocyte apoptotic process |
| recycling endosome membrane |
| regulation of alpha-beta T cell activation |
| positive regulation of T cell proliferation |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of adaptive immune response |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte proliferation |
| positive regulation of cytokine secretion |
| negative regulation of lymphocyte activation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of tumor necrosis factor superfamily cytokine production |
| early endosome membrane |
| regulation of T cell proliferation |
| regulation of adaptive immune response |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| cellular response to lipopolysaccharide |
| cellular response to molecule of bacterial origin |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| regulation of cytokine secretion |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| cellular response to biotic stimulus |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of leukocyte proliferation |
| positive regulation of cell-cell adhesion |
| positive regulation of protein secretion |
| negative regulation of cell adhesion |
| negative regulation of cytokine production |
| positive regulation of peptide secretion |
| regulation of leukocyte cell-cell adhesion |
| response to lipopolysaccharide |
| regulation of T cell activation |
| response to molecule of bacterial origin |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of secretion by cell |
| positive regulation of cell activation |
| positive regulation of protein transport |
| positive regulation of secretion |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of peptide secretion |
| positive regulation of cell migration |
| regulation of lymphocyte activation |
| cellular response to lipid |
| regulation of response to biotic stimulus |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| regulation of leukocyte activation |
| adaptive immune response |
| cell surface |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| regulation of cell migration |
| response to lipid |
| positive regulation of immune response |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| response to cytokine |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| positive regulation of developmental process |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| regulation of transport |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Actinomycin-D 0.01μM R00 exp4 | 1.77 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18126
- Expression level (log2 read counts): 0.62
Expression Distribution
CD274 Expression in NALM6 Cells: 0.62
