CD27 [The Human Chemical-Genetic Interaction Map Project]

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======= CD27 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD27
  * **<color #00a2e8>Official Name</color>**: CD27 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=939|939]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26842|P26842]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD27&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD27|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186711|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNFR c6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of B cell differentiation|
|negative regulation of T cell apoptotic process|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|regulation of B cell differentiation|
|negative regulation of lymphocyte apoptotic process|
|regulation of T cell apoptotic process|
|negative regulation of leukocyte apoptotic process|
|regulation of lymphocyte apoptotic process|
|positive regulation of NIK/NF-kappaB signaling|
|positive regulation of T cell differentiation|
|regulation of leukocyte apoptotic process|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|positive regulation of lymphocyte differentiation|
|extrinsic apoptotic signaling pathway|
|regulation of NIK/NF-kappaB signaling|
|tumor necrosis factor-mediated signaling pathway|
|response to ethanol|
|transmembrane signaling receptor activity|
|regulation of T cell differentiation|
|positive regulation of JNK cascade|
|positive regulation of leukocyte differentiation|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of JNK cascade|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|immunoglobulin mediated immune response|
|regulation of B cell activation|
|B cell mediated immunity|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte cell-cell adhesion|
|response to alcohol|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|positive regulation of cell-cell adhesion|
|response to tumor necrosis factor|
|lymphocyte mediated immunity|
|regulation of leukocyte differentiation|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|apoptotic signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|response to antibiotic|
|regulation of T cell activation|
|negative regulation of proteolysis|
|positive regulation of lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|regulation of hemopoiesis|
|negative regulation of hydrolase activity|
|response to toxic substance|
|regulation of lymphocyte activation|
|positive regulation of MAPK cascade|
|regulation of leukocyte activation|
|adaptive immune response|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|negative regulation of catalytic activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|immune effector process|
|response to cytokine|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.73|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14571
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD27 Expression in NALM6 Cells: -0.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>