CD27

Gene Information

Official Symbol: CD27
Official Name: CD27 molecule
Aliases and Previous Symbols: N/A
Entrez ID: 939
UniProt: P26842
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14571
Expression level (log2 read counts): -0.02

Expression Distribution

Screen	Score
Methotrexate 0.01μM R08 exp501	1.73
CFI-400945 25μM R08 exp469	1.9

positive regulation of B cell differentiation
negative regulation of T cell apoptotic process
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
regulation of B cell differentiation
negative regulation of lymphocyte apoptotic process
regulation of T cell apoptotic process
negative regulation of leukocyte apoptotic process
regulation of lymphocyte apoptotic process
positive regulation of NIK/NF-kappaB signaling
positive regulation of T cell differentiation
regulation of leukocyte apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cysteine-type endopeptidase activity
positive regulation of lymphocyte differentiation
extrinsic apoptotic signaling pathway
regulation of NIK/NF-kappaB signaling
tumor necrosis factor-mediated signaling pathway
response to ethanol
transmembrane signaling receptor activity
regulation of T cell differentiation
positive regulation of JNK cascade
positive regulation of leukocyte differentiation
positive regulation of stress-activated MAPK cascade
positive regulation of B cell activation
regulation of lymphocyte differentiation
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
positive regulation of hemopoiesis
positive regulation of T cell activation
immunoglobulin mediated immune response
regulation of B cell activation
B cell mediated immunity
regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of leukocyte cell-cell adhesion
response to alcohol
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
cellular response to tumor necrosis factor
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity