CD2 [The Human Chemical-Genetic Interaction Map Project]

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======= CD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD2
  * **<color #00a2e8>Official Name</color>**: CD2 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=914|914]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06729|P06729]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2-set|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of myeloid dendritic cell activation|
|membrane raft polarization|
|membrane raft distribution|
|membrane raft localization|
|regulation of myeloid dendritic cell activation|
|positive regulation of interferon-gamma secretion|
|regulation of interferon-gamma secretion|
|positive regulation of interleukin-8 secretion|
|membrane raft organization|
|regulation of interleukin-8 secretion|
|anchored component of plasma membrane|
|heterotypic cell-cell adhesion|
|positive regulation of interleukin-8 production|
|cytoplasmic side of plasma membrane|
|protein self-association|
|natural killer cell activation|
|receptor tyrosine kinase binding|
|positive regulation of interferon-gamma production|
|regulation of interleukin-8 production|
|localization within membrane|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of interferon-gamma production|
|regulation of T cell differentiation|
|positive regulation of cytokine secretion|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of lymphocyte differentiation|
|cell-cell junction|
|signaling receptor activity|
|regulation of cytokine secretion|
|membrane raft|
|T cell activation|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|positive regulation of peptide secretion|
|regulation of T cell activation|
|signaling receptor binding|
|leukocyte migration|
|lymphocyte activation|
|external side of plasma membrane|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|cell-cell adhesion|
|regulation of lymphocyte activation|
|protein-containing complex|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|membrane organization|
|protein homodimerization activity|
|apoptotic process|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|positive regulation of transport|
|regulation of protein localization|
|programmed cell death|
|cell activation|
|localization of cell|
|cell motility|
|cell death|
|positive regulation of immune system process|
|locomotion|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp169|BH1 1μM R04 exp169]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16064
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>