CD2

Entrez Summary: The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016].
UniProt Summary: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

C2-set
V-set

positive regulation of myeloid dendritic cell activation
membrane raft polarization
membrane raft distribution
membrane raft localization
regulation of myeloid dendritic cell activation
positive regulation of interferon-gamma secretion
regulation of interferon-gamma secretion
positive regulation of interleukin-8 secretion
membrane raft organization
regulation of interleukin-8 secretion
anchored component of plasma membrane
heterotypic cell-cell adhesion
positive regulation of interleukin-8 production
cytoplasmic side of plasma membrane
protein self-association
natural killer cell activation
receptor tyrosine kinase binding
positive regulation of interferon-gamma production
regulation of interleukin-8 production
localization within membrane
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
regulation of interferon-gamma production
regulation of T cell differentiation
positive regulation of cytokine secretion
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
regulation of lymphocyte differentiation
cell-cell junction
signaling receptor activity
regulation of cytokine secretion
membrane raft
T cell activation
positive regulation of protein secretion
regulation of leukocyte differentiation
positive regulation of peptide secretion
regulation of T cell activation
signaling receptor binding
leukocyte migration
lymphocyte activation