CD38 [The Human Chemical-Genetic Interaction Map Project]

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======= CD38 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD38
  * **<color #00a2e8>Official Name</color>**: CD38 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=952|952]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28907|P28907]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD38&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD38|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107270|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rib hydrolayse|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NAD+ nucleosidase activity|
|phosphorus-oxygen lyase activity|
|NAD(P)+ nucleosidase activity|
|NAD+ nucleotidase, cyclic ADP-ribose generating|
|artery smooth muscle contraction|
|tonic smooth muscle contraction|
|negative regulation of bone resorption|
|negative regulation of bone remodeling|
|vascular smooth muscle contraction|
|long-term synaptic depression|
|negative regulation of tissue remodeling|
|response to hydroperoxide|
|positive regulation of vasoconstriction|
|vasoconstriction|
|negative regulation of blood vessel diameter|
|regulation of bone resorption|
|positive regulation of B cell proliferation|
|response to progesterone|
|NAD metabolic process|
|regulation of bone remodeling|
|smooth muscle contraction|
|regulation of vasoconstriction|
|transferase activity|
|negative regulation of synaptic transmission|
|regulation of B cell proliferation|
|positive regulation of blood circulation|
|positive regulation of insulin secretion|
|regulation of tissue remodeling|
|positive regulation of peptide hormone secretion|
|secretory granule membrane|
|response to retinoic acid|
|positive regulation of hormone secretion|
|B cell receptor signaling pathway|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|response to estradiol|
|positive regulation of leukocyte proliferation|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|negative regulation of neuron projection development|
|positive regulation of cell growth|
|positive regulation of B cell activation|
|vascular process in circulatory system|
|regulation of insulin secretion|
|female pregnancy|
|negative regulation of cell projection organization|
|regulation of synaptic plasticity|
|response to ketone|
|basolateral plasma membrane|
|response to interleukin-1|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of peptide hormone secretion|
|regulation of mononuclear cell proliferation|
|multi-multicellular organism process|
|regulation of leukocyte proliferation|
|negative regulation of neuron differentiation|
|muscle contraction|
|positive regulation of growth|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of cytosolic calcium ion concentration|
|apoptotic signaling pathway|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|negative regulation of neurogenesis|
|antigen receptor-mediated signaling pathway|
|muscle system process|
|negative regulation of nervous system development|
|response to steroid hormone|
|regulation of cytosolic calcium ion concentration|
|negative regulation of cell development|
|response to hypoxia|
|response to acid chemical|
|response to decreased oxygen levels|
|positive regulation of lymphocyte activation|
|response to oxygen levels|
|response to oxidative stress|
|blood circulation|
|circulatory system process|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|regulation of cell growth|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|immune response-activating cell surface receptor signaling pathway|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|immune response-regulating cell surface receptor signaling pathway|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|regulation of lymphocyte activation|
|regulation of anatomical structure size|
|regulation of hormone levels|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|regulation of system process|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|cell surface|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|regulation of neurogenesis|
|response to lipid|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of transport|
|multi-organism reproductive process|
|negative regulation of cell death|
|response to drug|
|regulation of protein localization|
|programmed cell death|
|identical protein binding|
|cell death|
|response to cytokine|
|chemical homeostasis|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.7|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15187
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD38 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>