CD38
Gene Information
- Official Symbol: CD38
- Official Name: CD38 molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 952
- UniProt: P28907
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Pfam Domains GO Terms
Pfam Domains
| Rib hydrolayse |
GO Terms
| NAD+ nucleosidase activity |
| phosphorus-oxygen lyase activity |
| NAD(P)+ nucleosidase activity |
| NAD+ nucleotidase, cyclic ADP-ribose generating |
| artery smooth muscle contraction |
| tonic smooth muscle contraction |
| negative regulation of bone resorption |
| negative regulation of bone remodeling |
| vascular smooth muscle contraction |
| long-term synaptic depression |
| negative regulation of tissue remodeling |
| response to hydroperoxide |
| positive regulation of vasoconstriction |
| vasoconstriction |
| negative regulation of blood vessel diameter |
| regulation of bone resorption |
| positive regulation of B cell proliferation |
| response to progesterone |
| NAD metabolic process |
| regulation of bone remodeling |
| smooth muscle contraction |
| regulation of vasoconstriction |
| transferase activity |
| negative regulation of synaptic transmission |
| regulation of B cell proliferation |
| positive regulation of blood circulation |
| positive regulation of insulin secretion |
| regulation of tissue remodeling |
| positive regulation of peptide hormone secretion |
| secretory granule membrane |
| response to retinoic acid |
| positive regulation of hormone secretion |
| B cell receptor signaling pathway |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| response to estradiol |
| positive regulation of leukocyte proliferation |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| negative regulation of neuron projection development |
| positive regulation of cell growth |
| positive regulation of B cell activation |
| vascular process in circulatory system |
| regulation of insulin secretion |
| female pregnancy |
| negative regulation of cell projection organization |
| regulation of synaptic plasticity |
| response to ketone |
| basolateral plasma membrane |
| response to interleukin-1 |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of peptide hormone secretion |
| regulation of mononuclear cell proliferation |
| multi-multicellular organism process |
| regulation of leukocyte proliferation |
| negative regulation of neuron differentiation |
| muscle contraction |
| positive regulation of growth |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| positive regulation of cytosolic calcium ion concentration |
| apoptotic signaling pathway |
| regulation of blood circulation |
| positive regulation of peptide secretion |
| negative regulation of neurogenesis |
| antigen receptor-mediated signaling pathway |
| muscle system process |
| negative regulation of nervous system development |
| response to steroid hormone |
| regulation of cytosolic calcium ion concentration |
| negative regulation of cell development |
| response to hypoxia |
| response to acid chemical |
| response to decreased oxygen levels |
| positive regulation of lymphocyte activation |
| response to oxygen levels |
| response to oxidative stress |
| blood circulation |
| circulatory system process |
| positive regulation of leukocyte activation |
| positive regulation of secretion by cell |
| regulation of cell growth |
| positive regulation of cell activation |
| positive regulation of protein transport |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| immune response-activating cell surface receptor signaling pathway |
| calcium ion homeostasis |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| immune response-regulating cell surface receptor signaling pathway |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| regulation of neuron projection development |
| regulation of lymphocyte activation |
| regulation of anatomical structure size |
| regulation of hormone levels |
| cellular metal ion homeostasis |
| immune response-activating signal transduction |
| regulation of system process |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| cell surface |
| metal ion homeostasis |
| activation of immune response |
| cellular cation homeostasis |
| regulation of cell activation |
| cellular ion homeostasis |
| regulation of neuron differentiation |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| cation homeostasis |
| regulation of protein transport |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| regulation of neurogenesis |
| response to lipid |
| positive regulation of immune response |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of transport |
| multi-organism reproductive process |
| negative regulation of cell death |
| response to drug |
| regulation of protein localization |
| programmed cell death |
| identical protein binding |
| cell death |
| response to cytokine |
| chemical homeostasis |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| regulation of immune system process |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Hydroxychloroquine 30μM R08 exp490 | 1.7 |
| Taxol 0.002μM R01 exp54 | 1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15187
- Expression level (log2 read counts): 6.62
Expression Distribution
CD38 Expression in NALM6 Cells: 6.62
