CD46 [The Human Chemical-Genetic Interaction Map Project]

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======= CD46 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD46
  * **<color #00a2e8>Official Name</color>**: CD46 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4179|4179]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15529|P15529]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD46&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD46|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120920|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-10 production|
|inner acrosomal membrane|
|positive regulation of memory T cell differentiation|
|regulation of memory T cell differentiation|
|sequestering of extracellular ligand from receptor|
|extracellular regulation of signal transduction|
|extracellular negative regulation of signal transduction|
|positive regulation of regulatory T cell differentiation|
|positive regulation of transforming growth factor beta production|
|regulation of regulatory T cell differentiation|
|regulation of transforming growth factor beta production|
|positive regulation of interleukin-10 production|
|T cell mediated immunity|
|regulation of interleukin-10 production|
|virus receptor activity|
|positive regulation of T cell differentiation|
|positive regulation of lymphocyte differentiation|
|viral entry into host cell|
|positive regulation of T cell proliferation|
|entry into host|
|entry into host cell|
|regulation of Notch signaling pathway|
|regulation of complement activation|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|regulation of humoral immune response|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|single fertilization|
|positive regulation of leukocyte differentiation|
|cytokine production|
|interaction with host|
|regulation of T cell proliferation|
|complement activation, classical pathway|
|regulation of lymphocyte differentiation|
|humoral immune response mediated by circulating immunoglobulin|
|fertilization|
|complement activation|
|positive regulation of hemopoiesis|
|viral life cycle|
|positive regulation of T cell activation|
|signaling receptor activity|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|positive regulation of cell-cell adhesion|
|lymphocyte mediated immunity|
|regulation of leukocyte differentiation|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of leukocyte cell-cell adhesion|
|cadherin binding|
|regulation of T cell activation|
|humoral immune response|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|focal adhesion|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of immune effector process|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|adaptive immune response|
|cell surface|
|activation of immune response|
|regulation of cell activation|
|regulation of cell adhesion|
|regulation of cytokine production|
|viral process|
|innate immune response|
|leukocyte mediated immunity|
|symbiotic process|
|interspecies interaction between organisms|
|sexual reproduction|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|defense response to other organism|
|positive regulation of cell differentiation|
|multi-organism reproductive process|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|immune response|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13578
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD46 Expression in NALM6 Cells: 7.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>