CD46

Gene Information

Official Symbol: CD46
Official Name: CD46 molecule
Aliases and Previous Symbols: N/A
Entrez ID: 4179
UniProt: P15529
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13578
Expression level (log2 read counts): 7.62

Expression Distribution

interleukin-10 production
inner acrosomal membrane
positive regulation of memory T cell differentiation
regulation of memory T cell differentiation
sequestering of extracellular ligand from receptor
extracellular regulation of signal transduction
extracellular negative regulation of signal transduction
positive regulation of regulatory T cell differentiation
positive regulation of transforming growth factor beta production
regulation of regulatory T cell differentiation
regulation of transforming growth factor beta production
positive regulation of interleukin-10 production
T cell mediated immunity
regulation of interleukin-10 production
virus receptor activity
positive regulation of T cell differentiation
positive regulation of lymphocyte differentiation
viral entry into host cell
positive regulation of T cell proliferation
entry into host
entry into host cell
regulation of Notch signaling pathway
regulation of complement activation
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
regulation of humoral immune response
positive regulation of leukocyte proliferation
regulation of T cell differentiation
single fertilization
positive regulation of leukocyte differentiation
cytokine production
interaction with host
regulation of T cell proliferation
complement activation, classical pathway
regulation of lymphocyte differentiation
humoral immune response mediated by circulating immunoglobulin
fertilization
complement activation
positive regulation of hemopoiesis
viral life cycle