CD58 [The Human Chemical-Genetic Interaction Map Project]

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======= CD58 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD58
  * **<color #00a2e8>Official Name</color>**: CD58 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=965|965]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19256|P19256]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD58&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD58|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/153420|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of interleukin-8 secretion|
|regulation of interleukin-8 secretion|
|heterotypic cell-cell adhesion|
|positive regulation of interleukin-8 production|
|ficolin-1-rich granule membrane|
|regulation of interleukin-8 production|
|secretory granule membrane|
|positive regulation of cytokine secretion|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|regulation of cytokine secretion|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|signaling receptor binding|
|leukocyte migration|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|neutrophil mediated immunity|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|innate immune response|
|exocytosis|
|regulation of secretion|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cell migration|
|positive regulation of transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|response to cytokine|
|secretion|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9614
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD58 Expression in NALM6 Cells: 4.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>