CD58

Entrez Summary: N/A
UniProt Summary: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of interleukin-8 secretion
regulation of interleukin-8 secretion
heterotypic cell-cell adhesion
positive regulation of interleukin-8 production
ficolin-1-rich granule membrane
regulation of interleukin-8 production
secretory granule membrane
positive regulation of cytokine secretion
cellular response to interferon-gamma
response to interferon-gamma
regulation of cytokine secretion
cellular response to tumor necrosis factor
response to tumor necrosis factor
positive regulation of protein secretion
positive regulation of peptide secretion
signaling receptor binding
leukocyte migration
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of cytokine production
positive regulation of establishment of protein localization
regulation of protein secretion
neutrophil degranulation
neutrophil activation involved in immune response
regulation of peptide secretion
neutrophil mediated immunity
neutrophil activation
cell-cell adhesion
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
cell surface
leukocyte activation involved in immune response
cell activation involved in immune response
regulation of cytokine production
regulated exocytosis
regulation of protein transport