CD68

Entrez Summary: N/A
UniProt Summary: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of dendritic cell antigen processing and presentation
autocrine signaling
negative regulation of antigen processing and presentation
cellular response to oxidised low-density lipoprotein particle stimulus
regulation of dendritic cell antigen processing and presentation
regulation of antigen processing and presentation
inflammatory response to antigenic stimulus
response to lipoprotein particle
cellular response to lipoprotein particle stimulus
azurophil granule membrane
cell
late endosome membrane
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cellular response to biotic stimulus
cellular response to nutrient levels
lysosome
cellular response to extracellular stimulus
aging
lysosomal membrane
response to lipopolysaccharide
response to molecule of bacterial origin
cellular response to external stimulus
establishment of protein localization to organelle
negative regulation of immune system process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
inflammatory response
response to nutrient levels
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
cellular response to lipid
myeloid cell activation involved in immune response
response to extracellular stimulus
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response