CD79B [The Human Chemical-Genetic Interaction Map Project]

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======= CD79B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD79B
  * **<color #00a2e8>Official Name</color>**: CD79b molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=974|974]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40259|P40259]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD79B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD79B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147245|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269|PubMed:12097390, ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
|V-set|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|B cell receptor complex|
|B cell differentiation|
|B cell receptor signaling pathway|
|transmembrane signaling receptor activity|
|B cell activation|
|lymphocyte differentiation|
|antigen receptor-mediated signaling pathway|
|leukocyte differentiation|
|protein homooligomerization|
|lymphocyte activation|
|external side of plasma membrane|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|protein complex oligomerization|
|hemopoiesis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|activation of immune response|
|immune system development|
|response to bacterium|
|positive regulation of immune response|
|protein homodimerization activity|
|leukocyte activation|
|Golgi apparatus|
|cell activation|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|integral component of plasma membrane|
|protein-containing complex assembly|
|regulation of immune system process|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.82|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.08|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.96|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.93|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.82|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.75|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.76|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.77|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.77|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.79|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.82|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.84|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.87|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.95|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.01|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.11|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.18|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.2|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.42|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.43|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.79|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.91|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|3.11|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|3.61|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cd79a|CD79A]]|0.686|
|[[:human genes:i:igll1|IGLL1]]|0.679|
|[[:human genes:s:syk|SYK]]|0.658|
|[[:human genes:r:rhoh|RHOH]]|0.653|
|[[:human genes:e:ergic1|ERGIC1]]|0.615|
|[[:human genes:c:cd19|CD19]]|0.581|
|[[:human genes:p:pik3cd|PIK3CD]]|0.565|
|[[:human genes:s:ssr3|SSR3]]|0.459|
|[[:human genes:c:cd81|CD81]]|0.458|
|[[:human genes:r:rrm1|RRM1]]|0.457|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.453|
|[[:human genes:g:ganab|GANAB]]|0.453|
|[[:human genes:g:gna15|GNA15]]|0.41|
|[[:human genes:a:akt2|AKT2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1520
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD79B Expression in NALM6 Cells: 8.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>