CD79B

Entrez Summary: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
UniProt Summary: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269|PubMed:12097390, ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R02 exp89	-2.82
MK2206 4μM R08 exp504	-2.08
Tanespimycin 14μM R08 exp527	-1.96
Bleomycin 5μM R08 exp459	-1.93
Dorsomorphin 5μM R07 exp357	-1.82
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.75
Talazoparib 0.006μM R06 exp299	1.76
Aphidicolin 0.4μM R08 exp440	1.77
Rapamycin 0.001μM R08 exp429	1.77
Golgicide-A 4μM R03 exp122	1.79
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.82
Vincristine 0.0005μM R04 exp190	1.84
Methotrexate 0.01μM R08 exp501	1.87
UM0131023 0.05μM R05 exp248	1.95
Sulforaphane 9μM R08 exp526 no dilution day6	2.01
Pterostilbene 16μM R02 exp78	2.11
Hippuristanol 0.12μM R08 exp488	2.18
Citral 50μM R06 exp274	2.2
Mubritinib 0.2μM R01 exp48	2.42
Chloramphenicol 20μM R00 exp13	2.43
Trimetrexate 0.03μM R08 exp535	2.79
MLN-4924 0.2μM R00 exp21	2.91
Sulforaphane 9μM R08 exp525	3.11
Nifuroxazide 5μM R03 exp102	3.61
Arsenate 40μM R06 exp264	3.66

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

B cell receptor complex
B cell differentiation
B cell receptor signaling pathway
transmembrane signaling receptor activity
B cell activation
lymphocyte differentiation
antigen receptor-mediated signaling pathway
leukocyte differentiation
protein homooligomerization
lymphocyte activation
external side of plasma membrane
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
protein complex oligomerization
hemopoiesis
immune response-activating signal transduction
immune response-regulating signaling pathway
hematopoietic or lymphoid organ development
adaptive immune response
activation of immune response
immune system development
response to bacterium
positive regulation of immune response
protein homodimerization activity
leukocyte activation
Golgi apparatus
cell activation
positive regulation of immune system process
regulation of immune response
response to other organism
response to external biotic stimulus
response to biotic stimulus
integral component of plasma membrane
protein-containing complex assembly
regulation of immune system process
protein-containing complex subunit organization
immune response