CDC14B

Gene Information

Official Symbol: CDC14B
Official Name: cell division cycle 14B
Aliases and Previous Symbols: N/A
Entrez ID: 8555
UniProt: O60729
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. {ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:9367992}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14507
Expression level (log2 read counts): 2.46

Expression Distribution

positive regulation of ubiquitin protein ligase activity
signal transduction involved in G2 DNA damage checkpoint
mitotic cell cycle arrest
regulation of exit from mitosis
regulation of ubiquitin protein ligase activity
G2 DNA damage checkpoint
positive regulation of ubiquitin-protein transferase activity
positive regulation of cytokinesis
protein tyrosine/serine/threonine phosphatase activity
regulation of ubiquitin-protein transferase activity
protein serine/threonine phosphatase activity
signal transduction involved in DNA integrity checkpoint
signal transduction involved in DNA damage checkpoint
signal transduction involved in cell cycle checkpoint
mitotic spindle
positive regulation of cell division
regulation of cytokinesis
protein tyrosine phosphatase activity
negative regulation of cell cycle G2/M phase transition
peptidyl-tyrosine dephosphorylation
signal transduction in response to DNA damage
positive regulation of protein ubiquitination
spindle pole
DNA damage checkpoint
positive regulation of protein modification by small protein conjugation or removal
DNA integrity checkpoint
cell cycle arrest
regulation of cell division
regulation of mitotic nuclear division
regulation of nuclear division
cell cycle checkpoint
regulation of protein ubiquitination
regulation of cell cycle G2/M phase transition
protein dephosphorylation
regulation of protein modification by small protein conjugation or removal
negative regulation of cell cycle phase transition
positive regulation of cell cycle process
negative regulation of mitotic cell cycle
dephosphorylation
negative regulation of cell cycle process