CDC20 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CDC20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC20
  * **<color #00a2e8>Official Name</color>**: cell division cycle 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=991|991]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12834|Q12834]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603618|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. {ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-protein transferase activator activity|
|anaphase-promoting complex binding|
|positive regulation of synapse maturation|
|positive regulation of synaptic plasticity|
|positive regulation of ubiquitin protein ligase activity|
|regulation of synapse maturation|
|mitotic sister chromatid cohesion|
|anaphase-promoting complex|
|mitotic spindle checkpoint|
|spindle assembly checkpoint|
|regulation of ubiquitin protein ligase activity|
|mitotic spindle assembly checkpoint|
|spindle checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|negative regulation of mitotic sister chromatid segregation|
|regulation of meiotic nuclear division|
|negative regulation of sister chromatid segregation|
|positive regulation of ubiquitin-protein transferase activity|
|negative regulation of chromosome segregation|
|mitotic spindle assembly|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|sister chromatid cohesion|
|regulation of meiotic cell cycle|
|regulation of mitotic metaphase/anaphase transition|
|regulation of ubiquitin-protein transferase activity|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|mitotic spindle organization|
|regulation of sister chromatid segregation|
|anaphase-promoting complex-dependent catabolic process|
|spindle assembly|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|histone deacetylase binding|
|positive regulation of protein ubiquitination|
|spindle|
|spindle pole|
|positive regulation of protein modification by small protein conjugation or removal|
|negative regulation of chromosome organization|
|sister chromatid segregation|
|mitotic nuclear division|
|regulation of dendrite development|
|mitotic cell cycle checkpoint|
|spindle organization|
|regulation of reproductive process|
|regulation of mitotic nuclear division|
|protein C-terminus binding|
|regulation of synaptic plasticity|
|regulation of nuclear division|
|cell cycle checkpoint|
|regulation of protein ubiquitination|
|negative regulation of mitotic cell cycle phase transition|
|regulation of synapse organization|
|nuclear chromosome segregation|
|regulation of synapse structure or activity|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell cycle phase transition|
|chromosome segregation|
|protein deubiquitination|
|nuclear division|
|protein modification by small protein removal|
|negative regulation of mitotic cell cycle|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|enzyme binding|
|proteasomal protein catabolic process|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|regulation of mitotic cell cycle phase transition|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|regulation of neuron projection development|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of nervous system development|
|modification-dependent macromolecule catabolic process|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|microtubule-based process|
|mitotic cell cycle|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|regulation of cell cycle process|
|organelle assembly|
|protein modification by small protein conjugation|
|regulation of neurogenesis|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|generation of neurons|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.99|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.7|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.66|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.45|
|[[:results:exp539|42°C R08 exp539]]|-2.4|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.26|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.24|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.97|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.88|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.81|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.79|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.78|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.76|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.7|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.77|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.87|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.9|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.96|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.98|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.01|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.02|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.07|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.1|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|2.16|
|[[:results:exp131|L-74142 5μM R03 exp131]]|2.31|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.32|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.42|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|3.1|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|3.28|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|4.33|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|4.51|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|6.44|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|6.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zw10|ZW10]]|0.61|
|[[:human genes:k:kntc1|KNTC1]]|0.601|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.587|
|[[:human genes:h:hars|HARS]]|0.575|
|[[:human genes:t:trip13|TRIP13]]|0.573|
|[[:human genes:m:mad1l1|MAD1L1]]|0.535|
|[[:human genes:z:zwilch|ZWILCH]]|0.525|
|[[:human genes:b:bub1b|BUB1B]]|0.491|
|[[:human genes:r:rbm14|RBM14]]|0.479|
|[[:human genes:m:mad2l1|MAD2L1]]|0.452|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 736/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 934
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC20 Expression in NALM6 Cells: 7.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>