CDC20
Gene Information
- Official Symbol: CDC20
- Official Name: cell division cycle 20
- Aliases and Previous Symbols: N/A
- Entrez ID: 991
- UniProt: Q12834
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. {ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}.
Pfam Domains GO Terms
Pfam Domains
| WD40 |
GO Terms
| ubiquitin-protein transferase activator activity |
| anaphase-promoting complex binding |
| positive regulation of synapse maturation |
| positive regulation of synaptic plasticity |
| positive regulation of ubiquitin protein ligase activity |
| regulation of synapse maturation |
| mitotic sister chromatid cohesion |
| anaphase-promoting complex |
| mitotic spindle checkpoint |
| spindle assembly checkpoint |
| regulation of ubiquitin protein ligase activity |
| mitotic spindle assembly checkpoint |
| spindle checkpoint |
| negative regulation of mitotic metaphase/anaphase transition |
| negative regulation of metaphase/anaphase transition of cell cycle |
| negative regulation of mitotic sister chromatid separation |
| negative regulation of chromosome separation |
| negative regulation of mitotic sister chromatid segregation |
| regulation of meiotic nuclear division |
| negative regulation of sister chromatid segregation |
| positive regulation of ubiquitin-protein transferase activity |
| negative regulation of chromosome segregation |
| mitotic spindle assembly |
| negative regulation of mitotic nuclear division |
| negative regulation of nuclear division |
| sister chromatid cohesion |
| regulation of meiotic cell cycle |
| regulation of mitotic metaphase/anaphase transition |
| regulation of ubiquitin-protein transferase activity |
| regulation of metaphase/anaphase transition of cell cycle |
| regulation of mitotic sister chromatid separation |
| regulation of chromosome separation |
| regulation of mitotic sister chromatid segregation |
| mitotic spindle organization |
| regulation of sister chromatid segregation |
| anaphase-promoting complex-dependent catabolic process |
| spindle assembly |
| regulation of chromosome segregation |
| microtubule cytoskeleton organization involved in mitosis |
| mitotic sister chromatid segregation |
| histone deacetylase binding |
| positive regulation of protein ubiquitination |
| spindle |
| spindle pole |
| positive regulation of protein modification by small protein conjugation or removal |
| negative regulation of chromosome organization |
| sister chromatid segregation |
| mitotic nuclear division |
| regulation of dendrite development |
| mitotic cell cycle checkpoint |
| spindle organization |
| regulation of reproductive process |
| regulation of mitotic nuclear division |
| protein C-terminus binding |
| regulation of synaptic plasticity |
| regulation of nuclear division |
| cell cycle checkpoint |
| regulation of protein ubiquitination |
| negative regulation of mitotic cell cycle phase transition |
| regulation of synapse organization |
| nuclear chromosome segregation |
| regulation of synapse structure or activity |
| regulation of protein modification by small protein conjugation or removal |
| negative regulation of cell cycle phase transition |
| chromosome segregation |
| protein deubiquitination |
| nuclear division |
| protein modification by small protein removal |
| negative regulation of mitotic cell cycle |
| organelle fission |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| negative regulation of cell cycle process |
| enzyme binding |
| proteasomal protein catabolic process |
| regulation of chromosome organization |
| negative regulation of organelle organization |
| regulation of mitotic cell cycle phase transition |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of cell cycle phase transition |
| microtubule cytoskeleton organization |
| centrosome |
| cell division |
| regulation of neuron projection development |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| positive regulation of nervous system development |
| modification-dependent macromolecule catabolic process |
| negative regulation of cell cycle |
| proteolysis involved in cellular protein catabolic process |
| mitotic cell cycle process |
| cellular protein catabolic process |
| regulation of mitotic cell cycle |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| microtubule-based process |
| mitotic cell cycle |
| protein catabolic process |
| protein ubiquitination |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| regulation of cell cycle process |
| organelle assembly |
| protein modification by small protein conjugation |
| regulation of neurogenesis |
| cellular macromolecule catabolic process |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| regulation of transferase activity |
| protein modification by small protein conjugation or removal |
| cell cycle process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| chromosome organization |
| cytoskeleton organization |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| proteolysis |
| regulation of organelle organization |
| cell cycle |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| generation of neurons |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 736/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 27/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 934
- Expression level (log2 read counts): 7.23
Expression Distribution
CDC20 Expression in NALM6 Cells: 7.23
