CDC37 [The Human Chemical-Genetic Interaction Map Project]

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======= CDC37 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC37
  * **<color #00a2e8>Official Name</color>**: cell division cycle 37
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11140|11140]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16543|Q16543]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC37&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC37|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605065|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDC37 C|
|CDC37 M|
|CDC37 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|HSP90-CDC37 chaperone complex|
|positive regulation of mitophagy in response to mitochondrial depolarization|
|positive regulation of mitophagy|
|protein kinase regulator activity|
|chaperone complex|
|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|regulation of mitophagy|
|response to mitochondrial depolarisation|
|positive regulation of autophagy of mitochondrion|
|regulation of interferon-gamma-mediated signaling pathway|
|regulation of response to interferon-gamma|
|ERBB2 signaling pathway|
|regulation of type I interferon-mediated signaling pathway|
|Hsp90 protein binding|
|regulation of autophagy of mitochondrion|
|heat shock protein binding|
|scaffold protein binding|
|positive regulation of macroautophagy|
|ERBB signaling pathway|
|kinase binding|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|chaperone binding|
|regulation of cyclin-dependent protein kinase activity|
|positive regulation of mitochondrion organization|
|positive regulation of autophagy|
|unfolded protein binding|
|regulation of cytokine-mediated signaling pathway|
|regulation of macroautophagy|
|regulation of response to cytokine stimulus|
|protein stabilization|
|regulation of mitochondrion organization|
|protein folding|
|regulation of protein stability|
|regulation of autophagy|
|protein targeting|
|positive regulation of cellular catabolic process|
|positive regulation of catabolic process|
|regulation of innate immune response|
|protein kinase binding|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|positive regulation of organelle organization|
|enzyme linked receptor protein signaling pathway|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|regulation of transferase activity|
|regulation of catabolic process|
|intracellular protein transport|
|regulation of response to external stimulus|
|regulation of immune response|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of immune system process|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.21|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.17|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-2.03|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.03|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.96|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.94|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.94|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.92|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.89|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.86|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.85|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.84|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.83|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.83|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.78|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.76|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.74|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.73|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.72|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.72|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.72|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.71|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fntb|FNTB]]|0.427|
|[[:human genes:m:med16|MED16]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 528/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|21/28|
|bone|18/26|
|breast|27/33|
|central nervous system|36/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|14/16|
|kidney|13/21|
|liver|13/20|
|lung|46/75|
|lymphocyte|11/16|
|ovary|18/26|
|pancreas|17/24|
|peripheral nervous system|12/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|15/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|18/22|
|urinary tract|17/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 633
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC37 Expression in NALM6 Cells: 7.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>