CDC37

Gene Information

Official Symbol: CDC37
Official Name: cell division cycle 37
Aliases and Previous Symbols: N/A
Entrez ID: 11140
UniProt: Q16543
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epothilone-B 0.0015μM R05 exp231	-2.21
Vemurafenib 6.6μM R08 exp434	-2.17
CHIR-124 0.04μM R06 exp272	-2.03
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.03
PU-H71 1μM R08 exp515	-1.96
Nifuroxazide 5μM R03 exp102	-1.94
Rapamycin 1μM R00 exp29	-1.94
EPZ-5676 30μM R05 exp233	-1.92
Bisphenol S 100μM R08 exp458	-1.89
All-trans-Retinoic-Acid 40μM R07 exp334	-1.86
Actinomycin-D 0.001μM R00 exp3	-1.85
Milciclib 2μM R08 exp502	-1.84
Radicicol 0.16μM R05 exp242	-1.83
Thioridazine 5μM R08 exp530	-1.83
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.78
Heregulin-B 44ng/ml R08 exp486	-1.76
Glyphosate 1000μM R06 exp283	-1.74
BML-284 0.09μM R08 exp460	-1.73
Curcumin 6.5μM R06 exp277	-1.72
Ethanol 0.01 R05 exp234	-1.72
Golgicide-A 2μM R03 exp121	-1.72
Vinblastine 0.015μM R05 exp208	1.71
HMS-I1 10μM R06 exp256	2.21

Global Fraction of Cell Lines Where Essential: 528/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	21/28
bone	18/26
breast	27/33
central nervous system	36/56
cervix	4/4
colorectal	15/17
esophagus	10/13
fibroblast	0/1
gastric	14/16
kidney	13/21
liver	13/20
lung	46/75
lymphocyte	11/16
ovary	18/26
pancreas	17/24
peripheral nervous system	12/16
plasma cell	10/15
prostate	1/1
skin	15/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	18/22
urinary tract	17/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 633
Expression level (log2 read counts): 7.6

Expression Distribution

Gene	Correlation
FNTB	0.427
MED16	0.402

HSP90-CDC37 chaperone complex
positive regulation of mitophagy in response to mitochondrial depolarization
positive regulation of mitophagy
protein kinase regulator activity
chaperone complex
positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
regulation of autophagy of mitochondrion in response to mitochondrial depolarization
regulation of mitophagy
response to mitochondrial depolarisation
positive regulation of autophagy of mitochondrion
regulation of interferon-gamma-mediated signaling pathway
regulation of response to interferon-gamma
ERBB2 signaling pathway
regulation of type I interferon-mediated signaling pathway
Hsp90 protein binding
regulation of autophagy of mitochondrion
heat shock protein binding
scaffold protein binding
positive regulation of macroautophagy
ERBB signaling pathway
kinase binding
regulation of cyclin-dependent protein serine/threonine kinase activity
chaperone binding
regulation of cyclin-dependent protein kinase activity
positive regulation of mitochondrion organization
positive regulation of autophagy
unfolded protein binding
regulation of cytokine-mediated signaling pathway
regulation of macroautophagy
regulation of response to cytokine stimulus
protein stabilization
regulation of mitochondrion organization
protein folding
regulation of protein stability
regulation of autophagy
protein targeting
positive regulation of cellular catabolic process
positive regulation of catabolic process
regulation of innate immune response
protein kinase binding