CDC40

Entrez Summary: N/A
UniProt Summary: Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing. {ECO:0000269|PubMed:9830021}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 207/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	7/28
blood	7/28
bone	5/25
breast	13/33
central nervous system	9/56
cervix	3/4
colorectal	8/17
esophagus	5/13
fibroblast	1/1
gastric	3/15
kidney	5/21
liver	3/20
lung	30/75
lymphocyte	7/14
ovary	8/26
pancreas	7/24
peripheral nervous system	2/16
plasma cell	5/15
prostate	1/1
skin	2/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	8/22
urinary tract	7/29
uterus	2/5

Expression Distribution

U2-type catalytic step 2 spliceosome
mRNA 3-end processing
catalytic step 2 spliceosome
mRNA export from nucleus
mRNA-containing ribonucleoprotein complex export from nucleus
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
RNA 3-end processing
protein export from nucleus
mRNA transport
nuclear export
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
mRNA processing
mRNA metabolic process
RNA processing
intracellular protein transport
RNA binding
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
RNA metabolic process
establishment of localization in cell
nitrogen compound transport