CDC5L [The Human Chemical-Genetic Interaction Map Project]

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======= CDC5L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC5L
  * **<color #00a2e8>Official Name</color>**: cell division cycle 5 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=988|988]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99459|Q99459]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC5L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC5L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602868|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myb DNA-binding|
|DUF3351|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to wortmannin|
|response to wortmannin|
|cellular response to prolactin|
|response to prolactin|
|WD40-repeat domain binding|
|leucine zipper domain binding|
|cellular response to interleukin-2|
|response to interleukin-2|
|Prp19 complex|
|transcription corepressor binding|
|DNA replication factor A complex|
|protein phosphatase 1 binding|
|U2-type catalytic step 2 spliceosome|
|cellular response to nerve growth factor stimulus|
|response to nerve growth factor|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|catalytic step 2 spliceosome|
|cellular response to ketone|
|signal transduction in response to DNA damage|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|cell cycle checkpoint|
|response to ketone|
|cellular response to peptide hormone stimulus|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|cellular response to peptide|
|response to peptide hormone|
|RNA splicing|
|nuclear speck|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|protein kinase binding|
|response to peptide|
|mRNA processing|
|cellular response to growth factor stimulus|
|DNA repair|
|response to growth factor|
|cellular response to organic cyclic compound|
|negative regulation of cell cycle|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|mRNA metabolic process|
|perinuclear region of cytoplasm|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|RNA processing|
|response to hormone|
|response to organic cyclic compound|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|cell cycle|
|RNA binding|
|DNA binding|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.81|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.7|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.71|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.73|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.78|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.79|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.79|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.81|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.82|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.83|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.85|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.85|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.89|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.89|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.89|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.93|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.96|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.97|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.03|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.04|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.07|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.13|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.16|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.83|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.88|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|3.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.469|
|[[:human genes:a:arid4b|ARID4B]]|0.439|
|[[:human genes:r:rrp15|RRP15]]|0.429|
|[[:human genes:s:sf3a2|SF3A2]]|0.428|
|[[:human genes:p:plrg1|PLRG1]]|0.426|
|[[:human genes:c:ctage4|CTAGE4]]|0.417|
|[[:human genes:z:znf148|ZNF148]]|0.405|
|[[:human genes:p:prpf19|PRPF19]]|0.402|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.402|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.4|
|[[:human genes:k:kin|KIN]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 721/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|27/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1480
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC5L Expression in NALM6 Cells: 6.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>