CDC5L

Entrez Summary: N/A
UniProt Summary: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.81
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.7
A-395 10μM R05 exp218	1.71
Menadione 5μM R06 exp292	1.73
Lapatinib 5μM R01 exp47	1.78
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.79
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.79
CCT251545 20μM R07 exp326	1.81
THZ531 0.225μM R08 exp444	1.82
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.83
Latrunculin-B 10μM R07 exp374	1.85
UM0131023 0.05μM R05 exp248	1.85
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.89
Nutlin-3A 1.6μM R06 exp294	1.89
Temozolomide 200μM R04 exp189	1.89
TNF-alpha 44ng/ml R08 exp533	1.93
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.96
Betulinic acid 10 to 15μM on day4 R05 exp222	1.97
Myriocin 25μM R06 exp293	2.03
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.04
ML-792 0.2μM R08 exp505	2.07
Cytochalasin-B 5μM R07 exp349	2.13
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.16
THZ531 0.11μM R07 exp409	2.83
Rapamycin 10μM R00 exp30	2.88
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	3.24

Global Fraction of Cell Lines Where Essential: 721/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	27/28
bone	25/25
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Myb DNA-binding
DUF3351

cellular response to wortmannin
response to wortmannin
cellular response to prolactin
response to prolactin
WD40-repeat domain binding
leucine zipper domain binding
cellular response to interleukin-2
response to interleukin-2
Prp19 complex
transcription corepressor binding
DNA replication factor A complex
protein phosphatase 1 binding
U2-type catalytic step 2 spliceosome
cellular response to nerve growth factor stimulus
response to nerve growth factor
signal transduction involved in DNA integrity checkpoint
signal transduction involved in DNA damage checkpoint
signal transduction involved in cell cycle checkpoint
catalytic step 2 spliceosome
cellular response to ketone
signal transduction in response to DNA damage
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
DNA damage checkpoint
DNA integrity checkpoint
cell cycle checkpoint
response to ketone
cellular response to peptide hormone stimulus
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA polymerase II regulatory region sequence-specific DNA binding
cellular response to peptide
response to peptide hormone
RNA splicing
nuclear speck
DNA-binding transcription activator activity, RNA polymerase II-specific
protein kinase binding
response to peptide
mRNA processing