CDC6 [The Human Chemical-Genetic Interaction Map Project]

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======= CDC6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC6
  * **<color #00a2e8>Official Name</color>**: cell division cycle 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=990|990]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99741|Q99741]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602627|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA|
|Cdc6 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to vasopressin|
|response to vasopressin|
|traversing start control point of mitotic cell cycle|
|mitotic DNA replication checkpoint|
|DNA replication checkpoint|
|cellular response to angiotensin|
|DNA replication origin binding|
|spindle midzone|
|response to angiotensin|
|mitotic G2/M transition checkpoint|
|positive regulation of chromosome segregation|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|DNA replication initiation|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of cyclin-dependent protein kinase activity|
|positive regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cytokinesis|
|negative regulation of DNA replication|
|positive regulation of cell cycle G1/S phase transition|
|positive regulation of fibroblast proliferation|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|nucleotide binding|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|positive regulation of mitotic cell cycle phase transition|
|regulation of sister chromatid segregation|
|regulation of fibroblast proliferation|
|positive regulation of cell division|
|regulation of cytokinesis|
|negative regulation of G2/M transition of mitotic cell cycle|
|kinase binding|
|positive regulation of cell cycle phase transition|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cell cycle G2/M phase transition|
|regulation of chromosome segregation|
|regulation of cyclin-dependent protein kinase activity|
|mitotic DNA integrity checkpoint|
|regulation of DNA replication|
|G1/S transition of mitotic cell cycle|
|DNA-dependent DNA replication|
|cell cycle G1/S phase transition|
|spindle pole|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|regulation of mitotic nuclear division|
|regulation of cell division|
|regulation of nuclear division|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|DNA replication|
|negative regulation of cell cycle phase transition|
|cellular response to peptide hormone stimulus|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|cellular response to peptide|
|positive regulation of protein serine/threonine kinase activity|
|regulation of chromosome organization|
|positive regulation of cell cycle|
|response to peptide hormone|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|response to peptide|
|cell division|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of protein kinase activity|
|nucleolus|
|regulation of kinase activity|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of transferase activity|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.01|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.97|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.71|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.76|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.77|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.82|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.83|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.85|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.87|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.93|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.99|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.06|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.21|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfip11|TFIP11]]|0.576|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.565|
|[[:human genes:c:c14orf93|C14orf93]]|0.543|
|[[:human genes:t:tceb3c|TCEB3C]]|0.539|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.53|
|[[:human genes:r:rps5|RPS5]]|0.528|
|[[:human genes:s:snrpa1|SNRPA1]]|0.522|
|[[:human genes:p:psmb4|PSMB4]]|0.522|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.519|
|[[:human genes:c:cbwd6|CBWD6]]|0.511|
|[[:human genes:r:rps3a|RPS3A]]|0.51|
|[[:human genes:c:cdc73|CDC73]]|0.509|
|[[:human genes:o:orc6|ORC6]]|0.508|
|[[:human genes:s:sf3a1|SF3A1]]|0.507|
|[[:human genes:s:supt5h|SUPT5H]]|0.506|
|[[:human genes:o:orc1|ORC1]]|0.504|
|[[:human genes:t:ticrr|TICRR]]|0.504|
|[[:human genes:c:cbwd3|CBWD3]]|0.502|
|[[:human genes:d:dido1|DIDO1]]|0.496|
|[[:human genes:r:rps2|RPS2]]|0.495|
|[[:human genes:c:ckap5|CKAP5]]|0.494|
|[[:human genes:h:hap1|HAP1]]|0.493|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.493|
|[[:human genes:c:cep192|CEP192]]|0.493|
|[[:human genes:n:nbpf10|NBPF10]]|0.492|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.491|
|[[:human genes:m:mt1e|MT1E]]|0.49|
|[[:human genes:c:cactin|CACTIN]]|0.489|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.488|
|[[:human genes:c:cbwd5|CBWD5]]|0.488|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.482|
|[[:human genes:r:rpl14|RPL14]]|0.481|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.481|
|[[:human genes:d:dtl|DTL]]|0.481|
|[[:human genes:p:psmc1|PSMC1]]|0.481|
|[[:human genes:t:twistnb|TWISTNB]]|0.48|
|[[:human genes:n:nupl1|NUPL1]]|0.479|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.479|
|[[:human genes:r:rrp15|RRP15]]|0.479|
|[[:human genes:d:ddx56|DDX56]]|0.478|
|[[:human genes:s:sult2b1|SULT2B1]]|0.477|
|[[:human genes:r:riok2|RIOK2]]|0.476|
|[[:human genes:v:vasn|VASN]]|0.476|
|[[:human genes:p:psmd3|PSMD3]]|0.476|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.476|
|[[:human genes:k:kctd17|KCTD17]]|0.476|
|[[:human genes:r:rbm39|RBM39]]|0.474|
|[[:human genes:r:rpl35|RPL35]]|0.471|
|[[:human genes:c:chd4|CHD4]]|0.469|
|[[:human genes:r:rps12|RPS12]]|0.466|
|[[:human genes:c:cwc22|CWC22]]|0.466|
|[[:human genes:e:eif4a3|EIF4A3]]|0.463|
|[[:human genes:r:rad51|RAD51]]|0.462|
|[[:human genes:p:psma6|PSMA6]]|0.462|
|[[:human genes:m:myo1h|MYO1H]]|0.459|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.459|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.459|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.459|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.458|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.454|
|[[:human genes:g:golga8o|GOLGA8O]]|0.454|
|[[:human genes:a:adra1d|ADRA1D]]|0.453|
|[[:human genes:p:pcf11|PCF11]]|0.45|
|[[:human genes:n:npipb8|NPIPB8]]|0.448|
|[[:human genes:s:supt6h|SUPT6H]]|0.448|
|[[:human genes:a:aaas|AAAS]]|0.447|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.447|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.446|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.446|
|[[:human genes:e:egr2|EGR2]]|0.445|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.445|
|[[:human genes:n:nup160|NUP160]]|0.444|
|[[:human genes:t:timeless|TIMELESS]]|0.444|
|[[:human genes:s:sf3a3|SF3A3]]|0.443|
|[[:human genes:n:nup133|NUP133]]|0.443|
|[[:human genes:r:rnpc3|RNPC3]]|0.443|
|[[:human genes:p:psmc5|PSMC5]]|0.443|
|[[:human genes:c:ccna2|CCNA2]]|0.443|
|[[:human genes:p:psmb1|PSMB1]]|0.443|
|[[:human genes:s:stil|STIL]]|0.443|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.441|
|[[:human genes:e:exosc5|EXOSC5]]|0.44|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.44|
|[[:human genes:m:med17|MED17]]|0.44|
|[[:human genes:p:psmb2|PSMB2]]|0.439|
|[[:human genes:p:psmd6|PSMD6]]|0.438|
|[[:human genes:b:bysl|BYSL]]|0.438|
|[[:human genes:a:aqr|AQR]]|0.437|
|[[:human genes:c:cdc45|CDC45]]|0.436|
|[[:human genes:g:gon4l|GON4L]]|0.436|
|[[:human genes:n:nsf|NSF]]|0.435|
|[[:human genes:g:golga8j|GOLGA8J]]|0.435|
|[[:human genes:i:ints5|INTS5]]|0.433|
|[[:human genes:p:psma7|PSMA7]]|0.433|
|[[:human genes:p:pola2|POLA2]]|0.432|
|[[:human genes:n:nol10|NOL10]]|0.431|
|[[:human genes:s:ssh2|SSH2]]|0.429|
|[[:human genes:e:elmod3|ELMOD3]]|0.429|
|[[:human genes:p:plekha4|PLEKHA4]]|0.429|
|[[:human genes:i:ints6|INTS6]]|0.429|
|[[:human genes:c:cdca3|CDCA3]]|0.428|
|[[:human genes:a:acsf2|ACSF2]]|0.427|
|[[:human genes:p:polr2j3|POLR2J3]]|0.426|
|[[:human genes:c:chmp2a|CHMP2A]]|0.426|
|[[:human genes:p:plxnb3|PLXNB3]]|0.425|
|[[:human genes:i:ik|IK]]|0.425|
|[[:human genes:s:sf3a2|SF3A2]]|0.425|
|[[:human genes:t:tspy8|TSPY8]]|0.425|
|[[:human genes:n:ndc1|NDC1]]|0.423|
|[[:human genes:s:slc4a1|SLC4A1]]|0.423|
|[[:human genes:n:narfl|NARFL]]|0.422|
|[[:human genes:r:rpsa|RPSA]]|0.422|
|[[:human genes:t:top1mt|TOP1MT]]|0.421|
|[[:human genes:r:rrp7a|RRP7A]]|0.421|
|[[:human genes:r:rpl6|RPL6]]|0.421|
|[[:human genes:f:fbxw9|FBXW9]]|0.421|
|[[:human genes:p:plk4|PLK4]]|0.42|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.419|
|[[:human genes:z:znf106|ZNF106]]|0.419|
|[[:human genes:p:paf1|PAF1]]|0.419|
|[[:human genes:n:nup54|NUP54]]|0.418|
|[[:human genes:c:copg1|COPG1]]|0.418|
|[[:human genes:s:s1pr4|S1PR4]]|0.418|
|[[:human genes:r:rad21|RAD21]]|0.418|
|[[:human genes:l:lrr1|LRR1]]|0.418|
|[[:human genes:p:pwp2|PWP2]]|0.418|
|[[:human genes:r:rrn3|RRN3]]|0.418|
|[[:human genes:a:ahctf1|AHCTF1]]|0.417|
|[[:human genes:p:pole|POLE]]|0.417|
|[[:human genes:r:rps7|RPS7]]|0.417|
|[[:human genes:p:psmd1|PSMD1]]|0.417|
|[[:human genes:p:psmd2|PSMD2]]|0.417|
|[[:human genes:u:ubap1|UBAP1]]|0.417|
|[[:human genes:n:nufip2|NUFIP2]]|0.416|
|[[:human genes:s:snrnp70|SNRNP70]]|0.416|
|[[:human genes:g:gprin2|GPRIN2]]|0.415|
|[[:human genes:r:rps9|RPS9]]|0.415|
|[[:human genes:g:golga6a|GOLGA6A]]|0.415|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.415|
|[[:human genes:n:nup43|NUP43]]|0.414|
|[[:human genes:r:rrm2|RRM2]]|0.413|
|[[:human genes:s:sec13|SEC13]]|0.413|
|[[:human genes:m:myb|MYB]]|0.412|
|[[:human genes:a:ankle2|ANKLE2]]|0.412|
|[[:human genes:i:iscu|ISCU]]|0.412|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.412|
|[[:human genes:s:slc6a17|SLC6A17]]|0.412|
|[[:human genes:n:nup85|NUP85]]|0.411|
|[[:human genes:p:plk1|PLK1]]|0.411|
|[[:human genes:c:copa|COPA]]|0.411|
|[[:human genes:c:chaf1a|CHAF1A]]|0.411|
|[[:human genes:r:rnf113a|RNF113A]]|0.411|
|[[:human genes:a:akirin2|AKIRIN2]]|0.41|
|[[:human genes:i:igfn1|IGFN1]]|0.41|
|[[:human genes:c:cgb2|CGB2]]|0.409|
|[[:human genes:s:strn|STRN]]|0.409|
|[[:human genes:r:rpl34|RPL34]]|0.409|
|[[:human genes:z:znf148|ZNF148]]|0.408|
|[[:human genes:o:osbp|OSBP]]|0.408|
|[[:human genes:w:wdr75|WDR75]]|0.408|
|[[:human genes:m:msh5|MSH5]]|0.407|
|[[:human genes:n:nuf2|NUF2]]|0.407|
|[[:human genes:d:dock6|DOCK6]]|0.407|
|[[:human genes:r:rpa2|RPA2]]|0.407|
|[[:human genes:p:ppie|PPIE]]|0.406|
|[[:human genes:c:cmya5|CMYA5]]|0.406|
|[[:human genes:p:ppm1d|PPM1D]]|0.406|
|[[:human genes:t:tspy1|TSPY1]]|0.404|
|[[:human genes:a:aprt|APRT]]|0.404|
|[[:human genes:r:rilpl1|RILPL1]]|0.404|
|[[:human genes:c:cox8a|COX8A]]|0.403|
|[[:human genes:p:ppfia4|PPFIA4]]|0.403|
|[[:human genes:g:golga8h|GOLGA8H]]|0.402|
|[[:human genes:f:fam231c|FAM231C]]|0.402|
|[[:human genes:f:fam231a|FAM231A]]|0.402|
|[[:human genes:z:znf655|ZNF655]]|0.402|
|[[:human genes:n:nol12|NOL12]]|0.401|
|[[:human genes:f:fam160a1|FAM160A1]]|0.401|
|[[:human genes:t:terf2|TERF2]]|0.4|
|[[:human genes:p:psmd7|PSMD7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 670/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|20/28|
|bone|25/26|
|breast|30/33|
|central nervous system|49/56|
|cervix|3/4|
|colorectal|16/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|19/21|
|liver|20/20|
|lung|69/75|
|lymphocyte|13/16|
|ovary|25/26|
|pancreas|19/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|25/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 913
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC6 Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>