CDC6

Gene Information

Official Symbol: CDC6
Official Name: cell division cycle 6
Aliases and Previous Symbols: N/A
Entrez ID: 990
UniProt: Q99741
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 1μM R00 exp19	-2.01
Hinokiflavone 12μM R08 exp487	-1.97
Chlorpromazine 10μM R07 exp344	1.71
Losmapimod 1μM R07 exp376	1.76
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.77
Lapatinib 5μM R01 exp47	1.82
UM131593 0.1μM R01 exp58	1.83
Wortmannin 0.5μM R00 exp37	1.85
A-395N 10μM R05 exp219	1.87
MLN-4924 0.2μM R00 exp21	1.93
Sucrose 20000μM R06 exp298	1.99
Nifuroxazide 1μM R01 exp51	2
Rifampicin 10μM R00 exp32	2.06
GW501516 25μM R06 exp285	2.21
LB-100 2μM R05 exp210	2.81

Gene	Correlation
TFIP11	0.576
TCEB3CL2	0.565
C14orf93	0.543
TCEB3C	0.539
ATP6V1C1	0.53
RPS5	0.528
SNRPA1	0.522
PSMB4	0.522
TCEB3CL	0.519
CBWD6	0.511
RPS3A	0.51
CDC73	0.509
ORC6	0.508
SF3A1	0.507
SUPT5H	0.506
ORC1	0.504
TICRR	0.504
CBWD3	0.502
DIDO1	0.496
RPS2	0.495
CKAP5	0.494
HAP1	0.493
TBC1D3H	0.493
CEP192	0.493
NBPF10	0.492
TBC1D3F	0.491
MT1E	0.49
CACTIN	0.489
TBC1D3G	0.488
CBWD5	0.488
TBC1D3	0.482
RPL14	0.481
TBC1D3C	0.481
DTL	0.481
PSMC1	0.481
TWISTNB	0.48
NUPL1	0.479
HIST1H2BE	0.479
RRP15	0.479
DDX56	0.478
SULT2B1	0.477
RIOK2	0.476
VASN	0.476
PSMD3	0.476
C1QTNF9B	0.476
KCTD17	0.476
RBM39	0.474
RPL35	0.471
CHD4	0.469
RPS12	0.466
CWC22	0.466
EIF4A3	0.463
RAD51	0.462
PSMA6	0.462
MYO1H	0.459
TBC1D3L	0.459
TBC1D3E	0.459
TBC1D3I	0.459
TBC1D3K	0.458
PLA2G4F	0.454
GOLGA8O	0.454
ADRA1D	0.453
PCF11	0.45
NPIPB8	0.448
SUPT6H	0.448
AAAS	0.447
HIST2H2BF	0.447
DNTTIP2	0.446
GOLGA6L3	0.446
EGR2	0.445
CCDC64B	0.445
NUP160	0.444
TIMELESS	0.444
SF3A3	0.443
NUP133	0.443
RNPC3	0.443
PSMC5	0.443
CCNA2	0.443
PSMB1	0.443
STIL	0.443
C2orf27B	0.441
EXOSC5	0.44
GOLGA6L1	0.44
MED17	0.44
PSMB2	0.439
PSMD6	0.438
BYSL	0.438
AQR	0.437
CDC45	0.436
GON4L	0.436
NSF	0.435
GOLGA8J	0.435
INTS5	0.433
PSMA7	0.433
POLA2	0.432
NOL10	0.431
SSH2	0.429
ELMOD3	0.429
PLEKHA4	0.429
INTS6	0.429
CDCA3	0.428
ACSF2	0.427
POLR2J3	0.426
CHMP2A	0.426
PLXNB3	0.425
IK	0.425
SF3A2	0.425
TSPY8	0.425
NDC1	0.423
SLC4A1	0.423
NARFL	0.422
RPSA	0.422
TOP1MT	0.421
RRP7A	0.421
RPL6	0.421
FBXW9	0.421
PLK4	0.42
GOLGA6L4	0.419
ZNF106	0.419
PAF1	0.419
NUP54	0.418
COPG1	0.418
S1PR4	0.418
RAD21	0.418
LRR1	0.418
PWP2	0.418
RRN3	0.418
AHCTF1	0.417
POLE	0.417
RPS7	0.417
PSMD1	0.417
PSMD2	0.417
UBAP1	0.417
NUFIP2	0.416
SNRNP70	0.416
GPRIN2	0.415
RPS9	0.415
GOLGA6A	0.415
RPL7L1	0.415
NUP43	0.414
RRM2	0.413
SEC13	0.413
MYB	0.412
ANKLE2	0.412
ISCU	0.412
GOLGA6L6	0.412
SLC6A17	0.412
NUP85	0.411
PLK1	0.411
COPA	0.411
CHAF1A	0.411
RNF113A	0.411
AKIRIN2	0.41
IGFN1	0.41
CGB2	0.409
STRN	0.409
RPL34	0.409
ZNF148	0.408
OSBP	0.408
WDR75	0.408
MSH5	0.407
NUF2	0.407
DOCK6	0.407
RPA2	0.407
PPIE	0.406
CMYA5	0.406
PPM1D	0.406
TSPY1	0.404
APRT	0.404
RILPL1	0.404
COX8A	0.403
PPFIA4	0.403
GOLGA8H	0.402
FAM231C	0.402
FAM231A	0.402
ZNF655	0.402
NOL12	0.401
FAM160A1	0.401
TERF2	0.4
PSMD7	0.4

Global Fraction of Cell Lines Where Essential: 670/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	20/28
bone	25/26
breast	30/33
central nervous system	49/56
cervix	3/4
colorectal	16/17
esophagus	11/13
fibroblast	1/1
gastric	15/16
kidney	19/21
liver	20/20
lung	69/75
lymphocyte	13/16
ovary	25/26
pancreas	19/24
peripheral nervous system	16/16
plasma cell	13/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	18/22
urinary tract	25/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 913
Expression level (log2 read counts): 6.73

Expression Distribution

AAA
Cdc6 C

cellular response to vasopressin
response to vasopressin
traversing start control point of mitotic cell cycle
mitotic DNA replication checkpoint
DNA replication checkpoint
cellular response to angiotensin
DNA replication origin binding
spindle midzone
response to angiotensin
mitotic G2/M transition checkpoint
positive regulation of chromosome segregation
regulation of transcription involved in G1/S transition of mitotic cell cycle
DNA replication initiation
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of cyclin-dependent protein kinase activity
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of cytokinesis
negative regulation of DNA replication
positive regulation of cell cycle G1/S phase transition
positive regulation of fibroblast proliferation
regulation of mitotic metaphase/anaphase transition
regulation of metaphase/anaphase transition of cell cycle
regulation of mitotic sister chromatid separation
nucleotide binding
regulation of chromosome separation
regulation of mitotic sister chromatid segregation
positive regulation of mitotic cell cycle phase transition
regulation of sister chromatid segregation
regulation of fibroblast proliferation
positive regulation of cell division
regulation of cytokinesis
negative regulation of G2/M transition of mitotic cell cycle
kinase binding
positive regulation of cell cycle phase transition
regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle G2/M phase transition
regulation of chromosome segregation
regulation of cyclin-dependent protein kinase activity
mitotic DNA integrity checkpoint
regulation of DNA replication