CDC7 [The Human Chemical-Genetic Interaction Map Project]

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======= CDC7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC7
  * **<color #00a2e8>Official Name</color>**: cell division cycle 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8317|8317]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00311|O00311]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603311|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. {ECO:0000269|PubMed:12065429}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of nuclear cell cycle DNA replication|
|double-strand break repair via break-induced replication|
|positive regulation of DNA-dependent DNA replication|
|regulation of nuclear cell cycle DNA replication|
|positive regulation of G2/M transition of mitotic cell cycle|
|positive regulation of cell cycle G2/M phase transition|
|positive regulation of DNA replication|
|negative regulation of G0 to G1 transition|
|regulation of G0 to G1 transition|
|regulation of DNA-dependent DNA replication|
|intercellular bridge|
|positive regulation of mitotic cell cycle phase transition|
|mitotic spindle|
|kinase activity|
|peptidyl-threonine phosphorylation|
|peptidyl-threonine modification|
|positive regulation of cell cycle phase transition|
|double-strand break repair via homologous recombination|
|recombinational repair|
|regulation of DNA replication|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|positive regulation of mitotic cell cycle|
|peptidyl-serine phosphorylation|
|double-strand break repair|
|regulation of G2/M transition of mitotic cell cycle|
|peptidyl-serine modification|
|regulation of cell cycle G2/M phase transition|
|DNA replication|
|DNA recombination|
|protein kinase activity|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|negative regulation of cell cycle process|
|protein serine/threonine kinase activity|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell division|
|DNA repair|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|protein phosphorylation|
|cell cycle process|
|regulation of cell cycle|
|phosphorylation|
|cell cycle|
|ATP binding|
|regulation of cell population proliferation|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.95|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.72|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.77|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:disp2|DISP2]]|0.441|
|[[:human genes:a:atp1a3|ATP1A3]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 729/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|27/28|
|bone|25/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1798
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC7 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>