CDC7

Entrez Summary: N/A
UniProt Summary: Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. {ECO:0000269|PubMed:12065429}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 729/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	27/28
bone	25/26
breast	33/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Gene	Correlation
DISP2	0.441
ATP1A3	0.412

Pkinase
Pkinase Tyr

positive regulation of nuclear cell cycle DNA replication
double-strand break repair via break-induced replication
positive regulation of DNA-dependent DNA replication
regulation of nuclear cell cycle DNA replication
positive regulation of G2/M transition of mitotic cell cycle
positive regulation of cell cycle G2/M phase transition
positive regulation of DNA replication
negative regulation of G0 to G1 transition
regulation of G0 to G1 transition
regulation of DNA-dependent DNA replication
intercellular bridge
positive regulation of mitotic cell cycle phase transition
mitotic spindle
kinase activity
peptidyl-threonine phosphorylation
peptidyl-threonine modification
positive regulation of cell cycle phase transition
double-strand break repair via homologous recombination
recombinational repair
regulation of DNA replication
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
positive regulation of mitotic cell cycle
peptidyl-serine phosphorylation
double-strand break repair
regulation of G2/M transition of mitotic cell cycle
peptidyl-serine modification
regulation of cell cycle G2/M phase transition
DNA replication
DNA recombination
protein kinase activity
mitotic cell cycle phase transition
cell cycle phase transition
positive regulation of cell cycle process
negative regulation of cell cycle process
protein serine/threonine kinase activity
positive regulation of cell cycle
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
cell division