CDCA5 [The Human Chemical-Genetic Interaction Map Project]

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======= CDCA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDCA5
  * **<color #00a2e8>Official Name</color>**: cell division cycle associated 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=113130|113130]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96FF9|Q96FF9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDCA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDCA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609374|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sororin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cohesin loading|
|positive regulation of exit from mitosis|
|regulation of protein localization to chromatin|
|cohesin complex|
|mitotic sister chromatid cohesion|
|mitotic chromosome condensation|
|regulation of exit from mitosis|
|regulation of sister chromatid cohesion|
|chromosome condensation|
|mitotic metaphase plate congression|
|sister chromatid cohesion|
|positive regulation of mitotic nuclear division|
|chromosome, centromeric region|
|metaphase plate congression|
|positive regulation of nuclear division|
|establishment of chromosome localization|
|chromosome localization|
|positive regulation of mitotic cell cycle phase transition|
|regulation of sister chromatid segregation|
|positive regulation of cell cycle phase transition|
|regulation of chromosome segregation|
|mitotic sister chromatid segregation|
|chromosome|
|regulation of DNA binding|
|sister chromatid segregation|
|mitotic nuclear division|
|positive regulation of mitotic cell cycle|
|regulation of mitotic nuclear division|
|DNA packaging|
|double-strand break repair|
|regulation of nuclear division|
|nuclear chromosome segregation|
|nuclear chromatin|
|protein-containing complex binding|
|chromosome segregation|
|nuclear division|
|positive regulation of cell cycle process|
|DNA conformation change|
|organelle fission|
|regulation of chromosome organization|
|establishment of organelle localization|
|positive regulation of cell cycle|
|regulation of binding|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell division|
|DNA repair|
|regulation of cellular protein localization|
|organelle localization|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|regulation of cellular localization|
|cell cycle process|
|regulation of protein localization|
|chromosome organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|cellular response to stress|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.21|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.79|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.71|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.73|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.91|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.491|
|[[:human genes:p:polr2j3|POLR2J3]]|0.483|
|[[:human genes:c:col2a1|COL2A1]]|0.46|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.456|
|[[:human genes:f:fam160a1|FAM160A1]]|0.443|
|[[:human genes:z:znf830|ZNF830]]|0.442|
|[[:human genes:r:ranbp2|RANBP2]]|0.437|
|[[:human genes:c:copb2|COPB2]]|0.436|
|[[:human genes:b:bysl|BYSL]]|0.434|
|[[:human genes:a:ankle2|ANKLE2]]|0.434|
|[[:human genes:c:cep192|CEP192]]|0.427|
|[[:human genes:c:copa|COPA]]|0.424|
|[[:human genes:c:copg1|COPG1]]|0.423|
|[[:human genes:u:utp3|UTP3]]|0.422|
|[[:human genes:p:pan3|PAN3]]|0.421|
|[[:human genes:n:nupl1|NUPL1]]|0.42|
|[[:human genes:r:rpl35|RPL35]]|0.418|
|[[:human genes:o:osbp|OSBP]]|0.416|
|[[:human genes:n:npipb5|NPIPB5]]|0.416|
|[[:human genes:p:pigs|PIGS]]|0.416|
|[[:human genes:i:ik|IK]]|0.414|
|[[:human genes:k:krt78|KRT78]]|0.414|
|[[:human genes:c:cdca3|CDCA3]]|0.412|
|[[:human genes:c:crnkl1|CRNKL1]]|0.41|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.404|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.404|
|[[:human genes:p:psmb2|PSMB2]]|0.403|
|[[:human genes:p:psmd3|PSMD3]]|0.403|
|[[:human genes:o:or10g3|OR10G3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 428/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|17/28|
|bone|9/25|
|breast|16/33|
|central nervous system|35/56|
|cervix|3/4|
|colorectal|9/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|9/15|
|kidney|15/21|
|liver|18/20|
|lung|54/75|
|lymphocyte|6/14|
|ovary|15/26|
|pancreas|15/24|
|peripheral nervous system|11/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|4/7|
|thyroid|1/2|
|upper aerodigestive|12/22|
|urinary tract|12/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2240
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDCA5 Expression in NALM6 Cells: 7.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>