CDCA5

Entrez Summary: N/A
UniProt Summary: Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ML-792 0.2μM R08 exp505	-2.21
5-Fluorouracil 20μM R00 exp2	-1.79
Phenformin 20μM R03 exp143	-1.71
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.73
HMS-I2 1μM R06 exp286	1.91
Citral 50μM R06 exp274	2.03

Global Fraction of Cell Lines Where Essential: 428/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	18/28
blood	17/28
bone	9/25
breast	16/33
central nervous system	35/56
cervix	3/4
colorectal	9/17
esophagus	5/13
fibroblast	1/1
gastric	9/15
kidney	15/21
liver	18/20
lung	54/75
lymphocyte	6/14
ovary	15/26
pancreas	15/24
peripheral nervous system	11/16
plasma cell	3/15
prostate	0/1
skin	12/24
soft tissue	4/7
thyroid	1/2
upper aerodigestive	12/22
urinary tract	12/29
uterus	3/5

Expression Distribution

regulation of cohesin loading
positive regulation of exit from mitosis
regulation of protein localization to chromatin
cohesin complex
mitotic sister chromatid cohesion
mitotic chromosome condensation
regulation of exit from mitosis
regulation of sister chromatid cohesion
chromosome condensation
mitotic metaphase plate congression
sister chromatid cohesion
positive regulation of mitotic nuclear division
chromosome, centromeric region
metaphase plate congression
positive regulation of nuclear division
establishment of chromosome localization
chromosome localization
positive regulation of mitotic cell cycle phase transition
regulation of sister chromatid segregation
positive regulation of cell cycle phase transition
regulation of chromosome segregation
mitotic sister chromatid segregation
chromosome
regulation of DNA binding
sister chromatid segregation
mitotic nuclear division
positive regulation of mitotic cell cycle
regulation of mitotic nuclear division
DNA packaging
double-strand break repair
regulation of nuclear division
nuclear chromosome segregation
nuclear chromatin
protein-containing complex binding
chromosome segregation
nuclear division
positive regulation of cell cycle process
DNA conformation change
organelle fission
regulation of chromosome organization