CDH3

Gene Information

Official Symbol: CDH3
Official Name: cadherin 3
Aliases and Previous Symbols: N/A
Entrez ID: 1001
UniProt: P22223
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015].
UniProt Summary: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4585
Expression level (log2 read counts): 1.67

Expression Distribution

Cadherin C
Cadherin

positive regulation of monophenol monooxygenase activity
positive regulation of melanosome transport
negative regulation of timing of catagen
regulation of monophenol monooxygenase activity
regulation of hair cycle by canonical Wnt signaling pathway
regulation of melanosome transport
negative regulation of hair follicle maturation
negative regulation of transforming growth factor beta2 production
regulation of timing of catagen
negative regulation of hair follicle development
negative regulation of hair cycle
positive regulation of melanin biosynthetic process
positive regulation of secondary metabolite biosynthetic process
regulation of transforming growth factor beta2 production
negative regulation of transforming growth factor beta production
regulation of hair follicle maturation
regulation of melanin biosynthetic process
regulation of secondary metabolite biosynthetic process
positive regulation of keratinocyte proliferation
positive regulation of insulin-like growth factor receptor signaling pathway
regulation of secondary metabolic process
negative regulation of epidermis development
regulation of hair follicle development
regulation of insulin-like growth factor receptor signaling pathway
cell-cell adhesion mediated by cadherin
positive regulation of monooxygenase activity
regulation of hair cycle
catenin complex
regulation of keratinocyte proliferation
regulation of transforming growth factor beta production
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
positive regulation of oxidoreductase activity
regulation of monooxygenase activity
molting cycle process
retina homeostasis
hair cycle process
cytoskeletal protein binding
adherens junction organization
regulation of epidermis development
canonical Wnt signaling pathway