CDH5 [The Human Chemical-Genetic Interaction Map Project]

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======= CDH5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDH5
  * **<color #00a2e8>Official Name</color>**: cadherin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1003|1003]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P33151|P33151]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDH5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDH5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601120|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21269602}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin|
|Cadherin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of endothelial cell development|
|fibrinogen binding|
|positive regulation of establishment of endothelial barrier|
|vascular endothelial growth factor receptor 2 binding|
|blood vessel maturation|
|BMP receptor binding|
|negative regulation of microtubule polymerization|
|regulation of endothelial cell development|
|regulation of establishment of endothelial barrier|
|positive regulation of endothelial cell differentiation|
|regulation of establishment of cell polarity|
|regulation of establishment or maintenance of cell polarity|
|protein tyrosine kinase binding|
|cell-cell adhesion mediated by cadherin|
|catenin complex|
|positive regulation of BMP signaling pathway|
|regulation of endothelial cell differentiation|
|regulation of vascular permeability|
|negative regulation of microtubule polymerization or depolymerization|
|positive regulation of protein dephosphorylation|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|regulation of microtubule polymerization|
|positive regulation of dephosphorylation|
|positive regulation of epithelial cell differentiation|
|negative regulation of protein polymerization|
|cytoskeletal protein binding|
|regulation of microtubule polymerization or depolymerization|
|adherens junction organization|
|beta-catenin binding|
|protein phosphatase binding|
|regulation of BMP signaling pathway|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell-cell junction assembly|
|cell-cell adherens junction|
|bicellular tight junction|
|ion channel binding|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|anatomical structure maturation|
|negative regulation of inflammatory response|
|cell-cell junction organization|
|negative regulation of cytoskeleton organization|
|regulation of protein dephosphorylation|
|regulation of epithelial cell differentiation|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|positive regulation of angiogenesis|
|cell junction assembly|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|vascular process in circulatory system|
|cell-cell junction|
|positive regulation of vasculature development|
|regulation of microtubule cytoskeleton organization|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of defense response|
|regulation of dephosphorylation|
|cell junction organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|developmental maturation|
|positive regulation of protein complex assembly|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|cadherin binding|
|regulation of vasculature development|
|signaling receptor binding|
|regulation of inflammatory response|
|regulation of supramolecular fiber organization|
|negative regulation of response to external stimulus|
|negative regulation of organelle organization|
|blood circulation|
|external side of plasma membrane|
|circulatory system process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|regulation of protein complex assembly|
|cellular divalent inorganic cation homeostasis|
|blood vessel development|
|divalent inorganic cation homeostasis|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|cell junction|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|negative regulation of cell population proliferation|
|negative regulation of cellular component organization|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|calcium ion binding|
|cell morphogenesis|
|cellular chemical homeostasis|
|regulation of defense response|
|ion homeostasis|
|cellular component morphogenesis|
|regulation of cell migration|
|circulatory system development|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of cell motility|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of organelle organization|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|system process|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.81|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13779
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDH5 Expression in NALM6 Cells: -1.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>